Research Papers/Topics in Pharmaceutics

Evaluation of starches obtained from four Dioscorea species as binding agent in chloroquine phosphate tablet formulations

Abstract Starches obtained from four Dioscorea species namely Dioscorea dumetorum (Bitter), Dioscorea oppositifolia (Chinese), Dioscorea alata (Water), and Dioscorea rotundata (White) have been evaluated as binding agents in chloroquine phosphate tablet formulations in comparison with official corn starch. The compressional properties of the formulations were analyzed using density measurements and the Heckel and Kawakita equations. The mechanical properties of the tablets were assessed usin...

Repellent Action of Neem (Azadirachta indica) Seed Oil Cream against Anopheles Gambiae Mosquitoes

Abstract This paper conducted an evaluation of repellent effect of neem seed oil formulated in a vanishing type cream base against Anopheles gambiae mosquito under laboratory conditions using human volunteers. The seed oil was extracted and then prepared in five different concentrations of 0, 2.5, 5.0, 7.5 and 10.0% w /w respectively in a vanishing cream base. A commercially available repellent Deet was used as control. The result shows that concentrations 2.5, 5.0, 7.5, and 10.0% w /w and D...

In vitro evaluation of the antiviral activity of extracts from the lichen Parmelia perlata (L.) Ach. against three RNA viruses

ABSTRACT Background: Substances extracted from lichens have previously been reported to possess antimicrobial activities against various groups of bacteria, fungi and viruses. Due to the high abundance of Parmelia perlata in the Eastern parts of Nigeria, we decided to explore whether it possesses antiviral activity against some common animal and human viruses. Methodology: The dried and powdered lichen was extracted with acetone, water and 4% (v/v) NaOH (to yield a crude polysaccharide fracti...

Formulation factors affecting the binding properties of Chinese yam ( Dioscorea oppositifolia) and corn starches

Abstract Objective; The quantitative effects of formulation and processing variables affecting the binding properties of Chinese yam starch ( Dioscorea oppositifolia) in chloroquine phosphate tablet formulations have been investigated in comparison with com starch using a 23 factorial experimental design. Methods: Chinese yam starch, representing the "low " level, and com starch, representing the "high" level were used as binders at concentrations of 2. 5 % w /w and 10 % w /w in chloroquine ...

Lubricating Properties of Co-processed Coconut oil in Paracetamol Tablet Formulation

ABSTRACT  Objective: Lubricants are additives which reduce friction and so essential components of drug  formulation. This piece of work was initiated to evaluate coconut oil as a co-processed lubricant in  the formulation and compression of paracetamol tablets in comparison with magnesium stearatetalc as standard lubricant.  Methods: Various concentrations 0.5, 1.5, 2.0 and 2.5% w /w lubricant mixtures of magnesium  stearate-talc (MT), coconut magnesium stearate-talc (CMT), magnesium st...

Bio-activity and Spectral Analysis of Gas Chromatography/Mass Spectroscopy (GCMS) Profile of Crude Spomdias mombin Extracts

The purpose of this work is to determine the biological activity and spectral analysis of Gas chromatography/mass Spectroscopy (GC-MS) profile of crude extract of S monbin,S.mombin L. (Anacardiacaea) is a plant that grows in almost every part of the world. It is fruitferious decidous plant of about 20m high that grows in the rain forest of Africa. Smombin parts were harvested early in the morning into a polythene bag. S.mombin plant (1kg) each of the different plant parts was extracted with 3...

Qualitative and Quantitative Screening of Phytochemical Analysis of Spondias mombin (Linn.) Extracts (Root, Leaf and Stem Bark), A Useful Formulation in Drug Discovery

The objective of this is to determine the qualitative and quantitative screening of phytochemicalanalysis of Spondias mombin (Linn) extracts (root, leaf, and stem bark) using different extraction solvent. The root, leaf, and stem bark of Spondias mombin plant were harvested early in the morning into a polythene bag at Oja Oba market, IkareAkoko, Ondo State, a tropical rainforest of Nigeria with latitude (7.21692 North) and longitude (5.21561 East). The Spondias mombin. Powdered plant material...