ABSTRACT In recent years, mortality due to leptospirosis in dogs has been of major concern in Southwestern Nigeria, but the prevalent serovars, pathology and pathogenesis have not been fully documented. The purpose of this study was to investigate the disease in the dog and reservoir hosts (cattle and wild rats), and its pathogenesis and pathology in a guinea pig model. Between 2003 and 2010, 44 fresh and 60 formalin-fixed kidneys of tentatively diagnosed cases of canine leptospirosis o...