Research Papers/Topics in Applied Microbiology

Microfluidic chip for analyzing the effects of drugs and their dosage on the locomotion behavior of parasitic worms

This new microfluidic platform offers a more sensitive method for screening drugs and their effects on the locomotion of free living and parasitic nematodes. The chip is capable of monitoring four nematode parameters (number of worms responsive, number of worms leaving the drug well, average worm velocity and time until unresponsiveness) to provide a more detailed analysis and resolution of drug resistance. The drug screening experiment is divided into three parts: pre-exposure study, dose ex...