Research Papers/Topics in Biochemistry

Polyphenols as Potential Indicators for Drought Tolerance in Tea (Camellia sinensis L.)

Abstract: Plant polyphenols have gained prominence in quality of plant products and in human health. an experiment...(continue from the attached pdf)

Polypyrrole Based Biofunctional Composite Layer for Bioelectrocatalytic Device System

The involvement and development of intelligent polymers in enzymes as a catalyst have been interesting to develop processes that are environmentally benign, energy efficient, and selective towards their specific molecular applications. Polypyrrole based enzyme nanocomposites represents a continuous considerable redox organic polymer  that have been increased in electromechanical devices in advance  for  surface  functionalization. This review addresses the fundamental concepts of poly...

Sex-moderated relationship between the 2D:4D ratio and circulating hormones in an adult Ghanaian population

The second-to-fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D ratio or the right–left difference (Dr-l) are said to be negative and positive correlates, respectively, of circulating testosterone and estrogen in both adult males and females. However, previous studies on the subject have reported mixed results. This study aimed to determine the sex-moderated relationship between the 2D:4D ratio and adult circulating testosterone, estradiol, testostero...

Interactions between sex and the age at disease onset on cardiometabolic risk factors in a Ghanaian population with type 2 diabetes mellitus: A cross‐sectional study

Background and Aim: The are sex differences in cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) as well as the age at disease onset. However, the impact of these risk factors on the age at onset of T2DM is less known in the Ghanaian population. An understanding of the differential impact of cardiometabolic risk factors on the age at onset on T2DM may lead to sex‐specific interventions in preventive and management strategies for T2DM. Methods: The study was cross‐sectional f...

The Impact of Disease Duration on Sex Differences in Cardiometabolic Risk Factors in Type 2 Diabetic Patients on Metformin-glimepiride Oral Therapy

Aims: Patients with type 2 diabetes mellitus (T2DM) are commonly treated with metformin-glimepiride combination therapy. The relationship between disease duration and cardiometabolic risk factors among T2DM patients on metformin-glimepiride combination therapy may be moderated by sex. This, however, has not been investigated in the Ghanaian population. Study Design: This was a cross-sectional study. Place and Duration of Study: The study was conducted from January to December 2019 at the Bol...

Insulin Resistance in relation to Hypertension and Dyslipidaemia among Men Clinically Diagnosed with Type 2 Diabetes

Pathophysiologically, type 2 diabetes can result from insulin resistance or insulin insufficiency alone. It is unclear whether relative insulin shortage or pronounced insulin resistance is linked to poor cardiometabolic problems like obesity. Therefore, the objective of this study was to evaluate the relationship between insulin resistance (IR), hypertension, and dyslipidaemia, in men with type 2 diabetes mellitus. One hundred and twenty-one (121) type 2 diabetic men participated in this cros...

Phytomedical assessment of two Cymbopogon species found in Nkonkobe Municipality: toxicological effect on human Chang liver cell line

Abstract Background: Cymbopogon species are widely used as herbal remedies by the traditional healers living in Nkonkobe Municipality for the treatment and management of skin and respiratory infections. According to our survey, the plants seem to be very important because of the higher demands. Methods: The leaves of C. validis and C. plurinodis were hydro-distilled and the resulted extracted oils were analyzed by GC/MS. Minimum inhibitory concentrations (MICs) ranging from 7.8 to 500.0 μg/m...

Comparative Diagnostic Techniques for Cryptosporidium Infection

Abstract: Diarrhoea caused by Cryptosporidium is usually mild in immune competent individuals but severe in the young and those with underlying disease leading to compromised immunity. The conventional diagnosis of Cryptosporidium requires observation of the infective oocysts however, their tiny size yields indistinct results, thus limiting the effectiveness of the conventional diagnostic technique, modified Ziehl-Neelsen (ZN) differential staining. Consequent to the abovementioned limitatio...

In Vitro Antibacterial Activity of Sour Fig (Suurvy) Native to South Africa

Abstract: Sour figs have become a provincial demand in South Africa for the treatment of common infections. The plant has displayed antioxidant activity. The plant leaves were extracted with hexane, acetone, and ethanol using Stuart Sharker, UK. The extracts' antibacterial activity was evaluated by determining the MICs in a range of 7.8-500.0 μg/ml against ten strains using micro-well dilution. Cytotoxicity was evaluated with brine shrimp using the same concentrations. The hexane extract exh...

Antioxidant and phytochemical properties of Carpobrotus edulis (L.) bolus leaf used for the management of common infections in HIV/AIDS patients in Eastern Cape Province

Abstract Background: Carpobrotus edulis (Mesembryanthemaceae), also known as igcukuma in Xhosa language is a medicinal plant used by the traditional healers to treat common infections in HIV/AIDS patients. Based on this information, we researched on the plant phytoconstituents, as well as its inhibitory effect using aqueous and three different organic solvent extracts in order to justify its therapeutic usage. Methods: Antioxidant activity of the extracts were investigated spectrophotometri...

The inhibitory effect of Mesembryanthemum edule (L.) bolus essential oil on some pathogenic fungal isolate

Abstract Background: Mesembryanthemum edule is a medicinal plant which has been indicated by Xhosa traditional healers in the treatment HIV associated diseases such as tuberculosis, dysentery, diabetic mellitus, laryngitis, mouth infections, ringworm eczema and vaginal infections. The investigation of the essential oil of this plant could help to verify the rationale behind the use of the plant as a cure for these illnesses. Methods: The essential oil from M. edule was analysed by GC/MS. Co...

Micro-morphological Information of Carpobrotus edulis (L.) Bolus:A Southern African Herbal Plant

Background and Objective: Carpobrotus edulis has become one of the most recognized herbal plants in the Savanna Regions of Eastern Cape and Western Cape in South Africa. This study analyzed the foliar morphology and elemental composition of the plant Carpobrotus edulis (L.) bolus. Materials and Methods: Fresh leaves of the plant were investigated using the JEOL (JSM-6390LV) Scanning Electron Microscope (SEM). The elemental composition of the leaf was determined by Energy Dispersive X-ray Spe...

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

ABSTRACT Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARSCoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasi...

Hepatoprotective Potential of Alkaloid Extracts from Vitex doniana and Ficus thonningii Leaves in Alloxan-induced Diabetic Rats

Aim: This study sought to evaluate the hepatoprotective potential of alkaloid extracts from V. doniana and F. thonningii leaves on alloxan-induced diabetic rats. Materials and Methods: Fresh leaves of V. doniana and F. thonningii were obtained from a local market Nkwagu in Abakaliki local government area of Ebonyi State. They were dried and pulverized to fine granules using manual grinder. Crude alkaloid was extracted using standard method. The acute oral toxicity of both plants was determine...

Evaluation of Methanolic Extract of Bambara Nut on Renal Indices of Wistar Rats

Background: Bambara nut is a common household food in Nigeria especially among the Igbos ofthe South Eastern part of the country.Aim: This study is aimed at investigating the effect of Bambara nut on renal indices of Wistar rats.Methodology: The Songkhla 1 variety (red seed coat) of Bambara nuts were locally sourced in Obinze area of Owerri, Imo State, Nigeria. The seeds were peeled and ground to a fine powder using a coffee grinder and extracted using soxhlet apparatus and methanol as the so...


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