Pharmaceutical Microbiology Research Papers/Topics

Investigating the anti-filarial efficacy and molecular interactions of thiadiazol derivative: Insight from quantum chemical calculations, pharmacokinetics, and molecular docking studies

Abstract Parasitic infections such as lymphatic filariasis (elephantiasis) solely result from the infestation of a slender and thread-like worm. This condition precipitates swelling, often accompanied by skin alterations, potentially leading to substantial disability and disfigurement. Recent advancements in preventive measures for lymphatic filariasis encompass mass drug administration (MDA) involving antifilarial drugs. To that effect, this investigation employs an experimental and theoreti...

Investigating the anti-filarial efficacy and molecular interactions of thiadiazol derivative: Insight from quantum chemical calculations, pharmacokinetics, and molecular docking studies.

Abstract Parasitic infections such as lymphatic filariasis (elephantiasis) solely result from the infestation of a slender and thread-like worm. This condition precipitates swelling, often accompanied by skin alterations, potentially leading to substantial disability and disfigurement. Recent advancements in preventive measures for lymphatic filariasis encompass mass drug administration (MDA) involving antifilarial drugs. To that effect, this investigation employs an experimental and theoret...

Comparative study of the anti-eczema and antifungal activities of Mitracarpus scaber with Sulphur ointments, Hydraulic fluid and Skineal on eczematous skin

Abstract Eczema, an atopic dermatitis is one of the most economically important skin disorder, therefore remedial attention needs to be given to it. Unlike the orthodox belief, eczema is a genetic disorder of the epidermis (filaggrin, CARD 11 or KIF3A gene mutation) not an infection, therefore, treatment must be targeted towards correcting this rather than targeting Candida albicans, the yeast that infects the eczematous skin as a result of environmental exposure. Currently, all types of chem...

Antifungal Capacity of Lactic Acid Bacteria Isolated From Salad Vegetables

ABSTRACT This study explores the use of lactic acid bacteria from fresh salad vegetables to inhibit fungal growth. The antifungal assay was done using the agar well diffusion method as reported by Schillinger and Lucke (1989). The largest zone of inhibition (25mm) was recorded by the antagonistic activity of the isolate identified to Lactobacillus plantarum against Candida albicans ATCC 90029. No activity was recorded against Candida parapsilosis ATCC 22019, C. valida UCH 1508, C. pseudotrop...

In-vitro Antimicrobial Activities of Methanol Extracts of Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi

ABSTRACT   The antimicrobial activities of two Nigerian medicinal plant commonly used as chewing sticks Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi antimicrobial activities were investigated against 7clinical strains of Streptococcus mutans, Staphylococcus aureus ATCC 29213, Candida albicans, Candida tropicalis and Candida krusei ATCC 6825. The antibacterial and antifungal activities of the extracts were determined using the agar well diffusion and surface plate method respective...