SUMMARY Sensorineural hearing impairment (SIll) has been reported in chronic renal failure (CRF) patients with a prevalence of 20-40%. The aetiopathogenetic mechanisms reported included osmotic alteration resulting in loss of hair cells and in some, complications of haemodialysis have been hypothesized' We have in the past reported 2 cases of CRF patients who developed acute SHL following hemodialysis. This is a report of investigation of the effect of hemodialysis on the hearing function of...
ABSTRACT In recent years, mortality due to leptospirosis in dogs has been of major concern in Southwestern Nigeria, but the prevalent serovars, pathology and pathogenesis have not been fully documented. The purpose of this study was to investigate the disease in the dog and reservoir hosts (cattle and wild rats), and its pathogenesis and pathology in a guinea pig model. Between 2003 and 2010, 44 fresh and 60 formalin-fixed kidneys of tentatively diagnosed cases of canine leptospirosis obtain...
Abstract The paper explores the current situation and future development of nursing education and practice in Nigeria and their influence on health care. This is necessitated due to the significant advances in biomedical science and in the complexity of health care, coupled with observed shortage of nurses and the numerous reports of unsafe and poor quality of patient care, which have served as precursors to the concerns about nursing education and nursing practice in developed parts of the w...
ABSTRACT The efficiency of the sewage works depends on the quality and quantity of the influent and the design of the sewage works. Inefficiency of the sewage work has adverse health impact to the aquatic ecosystem. Pollutants can bio-accumulate and bio-magnify in the food chain causing health impact to both human being and wildlife. The main objective of this study was to assess the effectiveness of wastewater management system of Njoro industrial sewage works. This study used descriptive re...
ABSTRACT The use of pit latrines, their eventual fill up and need to desludge them expose humans and the environment to diseases associated with untreated excreta. Based on this, a study was done in Nakuru County to assess prescence of viable parasitic helminthes ova in faecal sludge and pit desludging and disposal practices used. Thirty five pit latrines were sampled and the prescence of parasitic helminthes ova determined at varius pit depths. Pit desludging and disposal practices was also ...
ABSTRACT A conceptual framework was developed in the context of community psychology for the development of a training programme in rape crisis intervention for lay therapists who were members of the Rape Crisis Organisation in Cape Town, South Africa. This framework was structured around the use of lay therapists, crisis intervention (including crisis intervention with rape victims) and consultation. The interrelationships of these three ·aspects were explored. The programme consi...
ABSTRACT FROM SALISBURY TO HARARE : THE GEOGRAPHY OF PUBLIC AUTHORITY FINANCE UNDER CHANGING IDEOLOGICAL CIRCUMSTANCES This study is based on the assumption that money 'powers the urban system'. Its focus is the geography of public finance in Harare and ideologically inspired change in urban management. The context is the changing circumstances attendant upon the transfer of power from minority White settler colonial rule to Black majority rule in Zimbabwe. The ruling ZANU-PF party professed ...
Abstract The tension between the increasing cost of healthcare provision and the need to provide a quality level of care to a rising number of people is a global phenomenon. A focus on one over the other could result in a rise in adverse patient outcomes, or a health system too costly to be sustainable. Clinical governance is an approach policymakers can use to walk the middle line of creating a healthcare service that meets quality of care standards in a cost-effective manner, as has been d...
Abstract The present study aimed to accelerate and improve accuracy of ɣ-aminobutyric acid (GABA) and glutathione (GSH) quantification. These metabolites, present at low concentrations in the brain, are challenging to detect using MR spectroscopy due to the fact that their resonance frequencies overlap with those of other more abundant metabolites. The advanced spectral editing techniques involving J-difference editing that are required to resolve the overlapping signals of these low concen...
List of abbreviations ......................................................................................................................................... 5 List of figures ................................................................................................................................................... 7 List of tables .................................................................................................................................................... 7 Sum...
ABSTRACT Introduction Paediatric Intensive Care has developed rapidly in recent years with a dramatic increase in survival rates. However, there are increasing concerns regarding the impact that admission to a Paediatric Intensive Care Unit (PICU) has on both the child and their family. Following discharge from PICU, children may be living with complex medical problems as well as dealing with the psychosocial impact that their illness has had on them and their family. Objectives To describ...
Table of Contents ! Declaration!............................................................................................................................................................!I! ! Acknowledgements!.......................................................................................................................................!III! ! Summary!..........................................................................................................................................
ABSTRACT Variegate porphyria (VP) is the clinical disorder associated with. a deficiency of the haemsynthesising enzyme protoporphyrinogen oxidase of the commonest monogenic inherited disorders in South Africa. The chmcal effects mclu~e p~otocutaneous sensitivity and the development of potentially life-threatening ~cute porp?ync cnses. . . Section 1 of this dissertation examines the molecular basIS for VP m South Africa. It IS shown to be a genetically heterogeneous disorder. The identificat...
ABSTRACT Two-dimensional X-ray imaging is the dominant imaging modality in low-resource countries despite the existence of three-dimensional (3D) imaging modalities. This is because fewer hospitals in low-resource countries can afford the 3D imaging systems as their acquisition and operation costs are higher. However, 3D images are desirable in a range of clinical applications, for example surgical planning. The aim of this research was to develop a tool for 3D approximation of scapula bone f...
Abstract Background: Heart failure (HF) is one of the most important causes of morbidity and mortality both in the developed and the developing nations. Acute heart failure (AHF) is a syndrome characterized by hospital admission for heart failure as defined by the presence of acute dyspnea and the presence of heart failure signs by physical examination with at least 2 of the following: rales, edema, elevated JVP, hepatomegaly and ascites. AHF can occur de novo or as worsening of symptoms in...