Abstract A common molecular variant of the angiotensinogen gene had been reported to predispose
some ethnic groups to hypertension. This case-control study was designed to determine the
frequency and association of the angiotensinogen M235T al1ele with hypertension in residents of
Calabar and Uyo cities, south-south Nigeria.
The study involved 1308 subjects, 612 patients and 696 controls. The M235T variant was investigated
using an allele specific polymerase chain reaction and enzymatic digestion to determine al1ele
frequencies. Hypertensinogenic factors such as dietary habits, physical activity, smoking and drinking
habits were assessed using questionnaires. Descriptive statistics, chi-square and multiple regression
analysis were used to analyze the data obtained.
The M235T al1ele frequency was high (0.94 for hypertensives and 0.96 for controls) though it was
not associated with hypertension status. The odds ratio for hypertension was 0.64 (95% confidence
interval: 0.39-1.06) there were no significant differences between the genotype frequency of hypertensives
and controls. By multiple regression, Hypertension was observed to be associated with age
and was a predictor for systolic blood pressure in both patient ,.2 = 0.359; p < 0.05 and control
groups ,.2 = 0.26.
Anumudu, C , Kooffreh, M & Akpan, E (2021). A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria. Afribary. Retrieved from https://afribary.com/works/a-study-of-the-m235t-variant-of-the-angiotensinogen-gene-and-hypertension-in-a-sample-population-of-calabar-and-uyo-nigeria
Anumudu, Chiaka et. al. "A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria" Afribary. Afribary, 21 Apr. 2021, https://afribary.com/works/a-study-of-the-m235t-variant-of-the-angiotensinogen-gene-and-hypertension-in-a-sample-population-of-calabar-and-uyo-nigeria. Accessed 18 Dec. 2024.
Anumudu, Chiaka, Mary Kooffreh and Effiong Akpan . "A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria". Afribary, Afribary, 21 Apr. 2021. Web. 18 Dec. 2024. < https://afribary.com/works/a-study-of-the-m235t-variant-of-the-angiotensinogen-gene-and-hypertension-in-a-sample-population-of-calabar-and-uyo-nigeria >.
Anumudu, Chiaka , Kooffreh, Mary and Akpan, Effiong . "A study of the M235T variant of the angiotensinogen gene and hypertension in a sample population of Calabar and Uyo, Nigeria" Afribary (2021). Accessed December 18, 2024. https://afribary.com/works/a-study-of-the-m235t-variant-of-the-angiotensinogen-gene-and-hypertension-in-a-sample-population-of-calabar-and-uyo-nigeria