Computerized Tomography Findings in Abdomen and Chest of Patients with Sickle Cell Disease


The study aimed to characterize the spleen in patients with SCD using

computerized tomography scan in all enhancement phases. The spleen

locations, shape, size, CT number and vascular findings were also been

evaluated. As well full depiction of the associated lesions characteristics were

studied at all types of SCD including hemoglobin SS, hemoglobin SC,

hemoglobin SB+ (Beta) thalassemia and Beta-Zero thalassemia. And the

complications occur in abdominal organs and chest were correlated according

to patient’s age and SCD types.

A total of 67 Saudi SCD patients were evaluated with CT in Ballasmar general

hospital and King Fahad central hospital during the period spanned from 2014-


The Study characterized the spleen in SCD patients ,it was found to be

extended until the lower third of the left kidney when it is enlarged by

percentage of 38%, and it can be oval, irregular, blurred out line with loss of

its normal medial concavity. The features of spleen size was variants to be

enlarged or shrunken present in 31 and 24 cases respectively. This changes in

spleen size was significantly correlated with the reduction of HU CT number

of the spleen at p≤0.004.

Study also found that there was a significant relation between the spleenic vein

dilatation and splenomegaly and those of enlarged lymph nodes at p≤0.00 and


CT scan contrast enhancement showed well characteristics of spleen lesions

occurred as complications from SCD (cysts, abscess and infarctions) and well

differentiation between them depending on the timing of intravenous bolus

administration of contrast material. Spleen abscess in all of the enhancement

phase in patients affected with sickle cell disease is well defined in both venus

and delay phase in 15 and 19 cases respectively, and 58.3% are peripherally

enhanced with hypodensity in the center of lesion, where most of the abscess

are ill defined in the arterial phase. Cysts are well enhanced in the arterial

phase which occurred in 7 patients, and most of them characterized by full

regular circle enhancement by percentage of 62.5%, while spleen infarction

showed well defined wedge-shaped based area of hypo attenuation which was

mostly peripheral without pressure effect on adjacent structures in the delay

phase which present in 66.6% of cases. On non-enhanced CT and arterial

enhancement, infarcts are poorly visualized.

The study also showed a significant relation between the character of the

lesions and degree of enhancement with the scanning technique used (pre

contrast, venous and delay phase) in different SCD types at p≤ 0.05.

The common SCD type was found to be hemoglobin SS where there are

significant relation between the type of the SCD and the character of the lesion

in the venous and delay phase at p≤0.037 and 0.055 in respectively.

Study found that the hepatic complications were, hepatic focal necrosis,

hepatomegaly, hepatic abscess, cyst and infarctions occurred in 8,19,12,10 and

10 patients respectively, while pancreatic and biliary complications were acute

pancreatitis and cholelithiasis present in 5 and 22 patients respectively. The

renal changes include renal papillary necrosis, renal abscess, stones with

hydronephrosis, renal vein thrombosis, renal failure and renal infarction found

in 15,7,11,4,7 and 11 patients respectively, as well the lung complications was

pleural effusion, pneumonia, atelectasis, ground glass nodules, consolidation,

fibrosis and lung abscess occurred in 16,6,4,5,8,10 and 7 patients respectively.

Study considering patients age and SCD types in all those previous abdominal

organs and chest complications.

The study concluded that, the findings of SCD complications can identified by

using MDCT at different CT scan phases.

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Ali, M (2021). Computerized Tomography Findings in Abdomen and Chest of Patients with Sickle Cell Disease. Afribary. Retrieved from

MLA 8th

Ali, Malaz "Computerized Tomography Findings in Abdomen and Chest of Patients with Sickle Cell Disease" Afribary. Afribary, 20 May. 2021, Accessed 22 Jul. 2024.


Ali, Malaz . "Computerized Tomography Findings in Abdomen and Chest of Patients with Sickle Cell Disease". Afribary, Afribary, 20 May. 2021. Web. 22 Jul. 2024. < >.


Ali, Malaz . "Computerized Tomography Findings in Abdomen and Chest of Patients with Sickle Cell Disease" Afribary (2021). Accessed July 22, 2024.