ABSTRACT
The purpose of the study was to evaluate the radioprotective effects of Gongronema latifolio
(GL) leaf extract on a whole-body irradiated wistar albino rats. A prospective experimental
and cross-sectional design was adopted for this study and it included a control group and
experimental group. Part of the control group (normal control NC) was not irradiated neither
was it administered with GL extract but the other part (experimental control EC) was only
exposed to graded radiation doses (GRDs). In the experimental group, the pre-treatment
group (PRT) received GL extract orally before being exposed to GRDs while post-treatment
group were exposed to GRDs before receiving GL extract orally.
Phytochemical analysis of GL extract was done to re-determine the bioactive constituents of
the extract. Physical changes were observed and recorded in all the groups using weight loss
as an index. The blood samples of the animal groups were collected before and after
irradiation (IR) for following analysis namely liver function test (LFT) {which includes-
Alkaline phosphase (ALP), Alanine amino-transferase (ALT), Aspatate amino-transferase
(AST)}, and antioxidant enzymes tests like Malondialdehyde (MDA), Glutathione (GSH),
Catalase (CAT) and Superoxide dismutase (SOD)}.
The result of the phytochemical analysis revealed the presence of the following bioactive
agents- alkaloids (3.11mg/g), tannins (2.43mg/g), flavonoids (1.31mg/g), phenols (1.10mg/g)
and saponin (0.8mg/g). Body weight of the rats exposed to 6Gy in EC (51g) significantly
(p0.05) different from PST (60g) group. ALP mean levels recorded in rats exposed to 4Gy
increased (p
STANISLAUS, O (2021). Evaluation Of Radioprotective Effect Of Gongronema Latifolio Leaf Extract On Whole-Body Irradiated Wistar Albino Rats. Afribary. Retrieved from https://afribary.com/works/evaluation-of-radioprotective-effect-of-gongronema-latifolio-leaf-extract-on-whole-body-irradiated-wistar-albino-rats
STANISLAUS, OKEKE "Evaluation Of Radioprotective Effect Of Gongronema Latifolio Leaf Extract On Whole-Body Irradiated Wistar Albino Rats" Afribary. Afribary, 15 May. 2021, https://afribary.com/works/evaluation-of-radioprotective-effect-of-gongronema-latifolio-leaf-extract-on-whole-body-irradiated-wistar-albino-rats. Accessed 22 Nov. 2024.
STANISLAUS, OKEKE . "Evaluation Of Radioprotective Effect Of Gongronema Latifolio Leaf Extract On Whole-Body Irradiated Wistar Albino Rats". Afribary, Afribary, 15 May. 2021. Web. 22 Nov. 2024. < https://afribary.com/works/evaluation-of-radioprotective-effect-of-gongronema-latifolio-leaf-extract-on-whole-body-irradiated-wistar-albino-rats >.
STANISLAUS, OKEKE . "Evaluation Of Radioprotective Effect Of Gongronema Latifolio Leaf Extract On Whole-Body Irradiated Wistar Albino Rats" Afribary (2021). Accessed November 22, 2024. https://afribary.com/works/evaluation-of-radioprotective-effect-of-gongronema-latifolio-leaf-extract-on-whole-body-irradiated-wistar-albino-rats