The development and spread of resistance to current antimalarial strategies underline the necessity to
develop innovative strategies. Recent studies suggest that ivermectin has a mosquitocidal effect
and ivermectin mass administration might become an effective and complementary strategy in
malaria elimination and eradication. However, ivermectin has been in use in many African
Countries for over 25 years in Mass Drug Administration for onchocerciasis and lymphatic
The purpose of the current study was to investigate whether there has been a change in malaria
prevalence in the months following ivermectin mass administration during the past three years.
A retrospective study was undertaken in the Navrongo War Memorial Hospital between May and
June 2015. Data from 2,652 randomly selected patients were extracted from consulting room
registers and admission and discharge books for the past three years. Variable of interest
included date of visit, diagnoses, age, sex and area of residence. Dates of ivermectin mass drug
administration were considered as point of reference. Malaria prevalence was compared three
months before and after ivermectin MDA using two-group test of proportions. Pearson Chisquare and logistic regression were used to determine factors associated with malaria prevalence
and strength of association.
On the whole, malaria prevalence was 24.8% (329/1,327, 95% CI: 22.5 - 27.1) before ivermectin
mass administration and 26.3% (349/1,325, 95% CI: 24.0 - 28.8) after ivermectin mass
administration with not statistically significant difference (-1.5%, 95% CI: -4.9 - 1.8; p = 0.361).
On annual basis, malaria prevalence after ivermectin mass administration significantly increased
during the year 2013 from 27 to 42% (p < 0.001) and decreased in 2014 from 20 to 14% (p =
0.016). Sex, age groups, source of data and year of ivermectin mass administration were found to
be significantly associated with malaria prevalence (p < 0.01). A stabilization or decrease was
observed when malaria baseline prevalence during the month preceding ivermectin mass
administration was low and lasted for about two months.
We hypothesize that ivermectin administered in MDA can be used as an effective tool to reduce
malaria prevalence. But its effectiveness will depend on the baseline prevalence before
ivermectin distribution and may last about two months. Further studies are needed to confirm
Edu, F (2021). Reported Malaria Cases At The War Memorial Hospital: Pre And Post Mass Administration Of Ivermectin In The Kassena-Nankana East And West Districts Of Ghana. Afribary.com: Retrieved May 13, 2021, from https://afribary.com/works/reported-malaria-cases-at-the-war-memorial-hospital-pre-and-post-mass-administration-of-ivermectin-in-the-kassena-nankana-east-and-west-districts-of-ghana
Frontiers, Edu. "Reported Malaria Cases At The War Memorial Hospital: Pre And Post Mass Administration Of Ivermectin In The Kassena-Nankana East And West Districts Of Ghana" Afribary.com. Afribary.com, 27 Apr. 2021, https://afribary.com/works/reported-malaria-cases-at-the-war-memorial-hospital-pre-and-post-mass-administration-of-ivermectin-in-the-kassena-nankana-east-and-west-districts-of-ghana . Accessed 13 May. 2021.
Frontiers, Edu. "Reported Malaria Cases At The War Memorial Hospital: Pre And Post Mass Administration Of Ivermectin In The Kassena-Nankana East And West Districts Of Ghana". Afribary.com, Afribary.com, 27 Apr. 2021. Web. 13 May. 2021. < https://afribary.com/works/reported-malaria-cases-at-the-war-memorial-hospital-pre-and-post-mass-administration-of-ivermectin-in-the-kassena-nankana-east-and-west-districts-of-ghana >.
Frontiers, Edu. "Reported Malaria Cases At The War Memorial Hospital: Pre And Post Mass Administration Of Ivermectin In The Kassena-Nankana East And West Districts Of Ghana" Afribary.com (2021). Accessed May 13, 2021. https://afribary.com/works/reported-malaria-cases-at-the-war-memorial-hospital-pre-and-post-mass-administration-of-ivermectin-in-the-kassena-nankana-east-and-west-districts-of-ghana