ABSTRACT Aim: To evaluate the anti-diabetic effect of aqueous extract of Saccharum officinarum (stem bark) in the genomic DNA of diabetic Wistar rats. Methodology: 15 Streptozotocin-induced diabetic male rats and five non diabetic rats were randomly and evenly distributed into four groups, and were subsequently exposed to the following treatments for 14 days: Group I (Control): Distilled water (1ml/kg B.W); Group II: Normal saline (1ml/kg B.W); Group III: treated Diabetic rats (Metformin) (50...