Background: Normal and abnormal development of anorectum is still under debate. Etiology of abnormal development of anorectum is poorly understood. Caffeine is a vasoconstrictor that has been implicated in abnormal anorectal development and is a major constituent of Kola nut (Cola nitida). It is consumed heavily by pregnant women in Nigeria to control vomiting. Objectives: We examined the teratogenic effects of oral administration of aqueous extract of Cola nitida (AECON) on foetal growth a...
