Phylogenetic and In Silico Analysis of Niemann-pick type C1 (NPC1) Transporter Required for Ebola Viral Entry
Ebola virus (EBOV) has recently emerged as a highly virulent organism of concern to humans. The pathology behind the hemorrhagic fever within an EBOV host remains largely unclear, and demands rather novel therapeutics to effectively eradicate this virus. The Niemann-pick type C1 (NPC1) protein cholesterol transporter is required for EBOV entry and internalization into a mammalian host cell. On this premise, an organism’s NPC1 can decide the virus-species specificity. Here, ...