The Concept of Nonribosomal Peptide Sythetases: Industrial Application in Biosynthesis of Antibiotics
Abstract Nonribosomal peptide synthetases (NRPSs) are multimodular enzymes that are used wholly or partly in the biosynthesis of antiobiotics; a natural product that fall into the class of secondary metabolites. NRPSs have diverse functions and have also been used in the synthesis of toxins, siderophores, or pigments, among others. Unlike other proteins, its biosynthesis is independent of ribosomal machinery. Nonribosomal peptides are synthesized on large nonribosomal peptide synthetase�...