ABSTRACT
Vitamin D is a lipid soluble vitamin that acts as a hormone as well as a micronutrient. Through vitamin D receptors (VDR) expressed on immune cells, vitamin D polarizes Th1/Th2 cytokine balance in pregnancy regulating humoral immune responses triggered by B cell antigens. How plasma concentrations of 25-hydroxyvitamin D affect the quantity of anti-measles virus and anti-diphtheria toxoid vaccine-antigen antibodies during pregnancy in early life years remain unclear. This study assumed that vitamin D affects antibody responses to infections and therefore investigated its association with IgG levels following measles virus and diphtheria toxoid vaccination during childhood. Specifically, the study quantified plasma concentrations of 25 (OH) D, anti measles virus and anti diphtheria toxoid IgG, and computed the association between 25(OH) D and the vaccine-induced IgG responses in mother-child pairs. This was a hospital-based prospective cohort study of pregnant mothers from their first trimester to delivery; and mother-infant pairs from delivery/birth up to 18 months old. Mothers attending antenatal care at Chulaimbo Sub-County hospital were enrolled in their first trimester and followed up to delivery. Infants were followed up from delivery to 18 months old at 6 months interval. Plasma was freshly processed from the blood samples, and stored at -80oC before bio-assaying. Plasma concentration of 25(OH) D was measured by enzyme immuno-sorbent assay technique (EIA) in vivo at ANC1,2,3 and 4/delivery in mothers; in cord blood, at 6, 12 and 18 months in children. Anti-measles virus and anti-diphtheria toxoid vaccine IgG antibody levels were quantified using commercially available ELISA kits at delivery in mothers; in cord blood, at 6, 12 and 18 months in children. Data was analysed from 47 mother-child pairs. Vitamin D quantifications showed that, at delivery, 8.51% (4) of the mothers were deficient (
EUNICE, N (2021). Association Of Vitamin D With Measles Virus And Diphtheria Toxoid Specific Vaccine Antigen Immunoglobulin G Responses In Mother - Child Pairs At Chulaimbo Sub-County Hospital In Western Kenya. Afribary. Retrieved from https://afribary.com/works/association-of-vitamin-d-with-measles-virus-and-diphtheria-toxoid-specific-vaccine-antigen-immunoglobulin-g-responses-in-mother-child-pairs-at-chulaimbo-sub-county-hospital-in-western-kenya
EUNICE, NAMUYENGA "Association Of Vitamin D With Measles Virus And Diphtheria Toxoid Specific Vaccine Antigen Immunoglobulin G Responses In Mother - Child Pairs At Chulaimbo Sub-County Hospital In Western Kenya" Afribary. Afribary, 07 May. 2021, https://afribary.com/works/association-of-vitamin-d-with-measles-virus-and-diphtheria-toxoid-specific-vaccine-antigen-immunoglobulin-g-responses-in-mother-child-pairs-at-chulaimbo-sub-county-hospital-in-western-kenya. Accessed 03 May. 2024.
EUNICE, NAMUYENGA . "Association Of Vitamin D With Measles Virus And Diphtheria Toxoid Specific Vaccine Antigen Immunoglobulin G Responses In Mother - Child Pairs At Chulaimbo Sub-County Hospital In Western Kenya". Afribary, Afribary, 07 May. 2021. Web. 03 May. 2024. < https://afribary.com/works/association-of-vitamin-d-with-measles-virus-and-diphtheria-toxoid-specific-vaccine-antigen-immunoglobulin-g-responses-in-mother-child-pairs-at-chulaimbo-sub-county-hospital-in-western-kenya >.
EUNICE, NAMUYENGA . "Association Of Vitamin D With Measles Virus And Diphtheria Toxoid Specific Vaccine Antigen Immunoglobulin G Responses In Mother - Child Pairs At Chulaimbo Sub-County Hospital In Western Kenya" Afribary (2021). Accessed May 03, 2024. https://afribary.com/works/association-of-vitamin-d-with-measles-virus-and-diphtheria-toxoid-specific-vaccine-antigen-immunoglobulin-g-responses-in-mother-child-pairs-at-chulaimbo-sub-county-hospital-in-western-kenya