Determination of Correlation between Platelet Parameters and Complications of Type2 Diabetes Mellitus in Sudanese Patients in Khartoum State

Abstract

This case control study was conducted to determine the association between platelet parameters and complications of type2 diabetes mellitus in Sudanese patients in Khartoum state during the period from August to November 2018.

150 participants of age between 28-65 years were selected randomly (50 of them complain from diabetes mellitus, 50 have diabetic complications and the others are apparent healthy participate as controls). Ethyline Diamine Tetra Acetic acid anti-coagulated venous blood sample (3ml) was collected from each subject. Platelet parameters were measured using automated hematological analyzer (Mindry BC2800) in Nourin’s medical center.

The data analyzed using statistical package of social science programme, the statistical results revealed that there is significant difference in mean platelet volume (8.4±1.3fl vs. 7.9±0.7fl p=0.025) and platelet distribution width (14.1±1.9fl vs.15.4±0.2fl p=0.000) between diabetic patients and healthy participants. The mean of platelet count, mean platelet volume and plateletcrit were significantly increased in diabetic patients with complications as compared to diabetic patients without complication and control group (294±77×109/L vs.257±67×109/L p=0.003, 9.1±1.4fl vs.7.8±0.7fl p=0.000 and 0.266±0.06 vs.0.201±0.05 p=0.000 respectively) while platelet distribution width was significantly decreased (13.0±2.1fl vs.15.4±0.2fl p=0.000) By the end of this study, it was revealed that platelet indices (mainly the mean platelet volume and plateletcrit could be used as a prognostic markers for early detection of diabetic complications.