Epidemiological Study of Urogenital Schistosomiasis in Apparently Healthy And HIV Infected Females in Jos, Plateau State, Nigeria

Abstract

This study is aimed at determining the status, prevalence and significance of female urogenital schistosomiasis (FUGS) in schistosomiasis endemic population at risk of HIV transmission in Jos, Plateau State. Epidemiological circumstances that predisposed individuals to urogenital schistosomiasis and HIV in Jos Plateau State, was investigated. FUGS was determined from parasitological and immunological techniques. Circulating cathodic (worm) antigen (CCA) was used as an additional immunodiagnostic tool to measure the worm burden of the study population. Commercial ELISA was used to determine HIV status while CCA and cytokine plasma levels were used to assess pathology and determine indices of FUGS. Immunological studies to provide evidence of FUGS morbidity, to establish the presence of immunopathology and other markers of FUGS were carried out using important regulatory T - cells and cytokines involved in cellular and humoral immune response. The physical nature and chemistry profile of study subjects were determined for urinary tract pathology, using urinalysis test strips. Data analyses, using expressive percentage, parametric and non-parametric tests were used to assess the significance of varied observations. Two Way analysis of variance was used for multiple comparisons while regression for linear relationships, were applied appropriately. Observations were confirmed significant at p = 0.05 in SPSS version 15.1 and all statistics; while Optical Density values were transformed by ELISA LogIt 2005 software. One thousand, two hundred and forty-five (1245) females were screened for S. haematobium. Urogenital schistosomiasis was confirmed in 265 (26.3%), in 11-20 year olds (28.3%) accounting for the highest infections (p < 0.05). HIV infection was 27(6.8%) and (9.4%) in 21-30 year olds. Students accounted for most infection (39.7%). Only 5.3% urinary schistosomiasis/HIV co-infections were recorded. Economic activities including, irrigation agriculture and domestic chores accounted for most water contacts (64.8%). About 70.9 % (381) presented with indices of FUGS pathology, including: blood, nitrate, xv protein, leucocyte in >45% of positive persons. Worm burden (from CCA level) was as high as 127 (67.8%; p > 0.05) among study groups. About 79.3% schistosomiasis and HIV infected groups expressed high level of IFN-γ (5-fold, p < 0.05). Tumor necrosis factoralpha (TNF-α) revealed elevation in 58.0% of the schistosomiasis, HIV and HIV/schistosomiasis co-infected subjects (p

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APA

NJOKU, J (2021). Epidemiological Study of Urogenital Schistosomiasis in Apparently Healthy And HIV Infected Females in Jos, Plateau State, Nigeria. Afribary. Retrieved from https://afribary.com/works/epidemiological-study-of-urogenital-schistosomiasis-in-apparently-healthy-and-hiv-infected-females-in-jos-plateau-state-nigeria

MLA 8th

NJOKU, JANE "Epidemiological Study of Urogenital Schistosomiasis in Apparently Healthy And HIV Infected Females in Jos, Plateau State, Nigeria" Afribary. Afribary, 09 Apr. 2021, https://afribary.com/works/epidemiological-study-of-urogenital-schistosomiasis-in-apparently-healthy-and-hiv-infected-females-in-jos-plateau-state-nigeria. Accessed 19 Jul. 2024.

MLA7

NJOKU, JANE . "Epidemiological Study of Urogenital Schistosomiasis in Apparently Healthy And HIV Infected Females in Jos, Plateau State, Nigeria". Afribary, Afribary, 09 Apr. 2021. Web. 19 Jul. 2024. < https://afribary.com/works/epidemiological-study-of-urogenital-schistosomiasis-in-apparently-healthy-and-hiv-infected-females-in-jos-plateau-state-nigeria >.

Chicago

NJOKU, JANE . "Epidemiological Study of Urogenital Schistosomiasis in Apparently Healthy And HIV Infected Females in Jos, Plateau State, Nigeria" Afribary (2021). Accessed July 19, 2024. https://afribary.com/works/epidemiological-study-of-urogenital-schistosomiasis-in-apparently-healthy-and-hiv-infected-females-in-jos-plateau-state-nigeria

Document Details
JANE CHIZOMA NJOKU Field: Zoology Type: Thesis 250 PAGES (56885 WORDS) (pdf)