Many adults with sickle cell disease (SCD) complain of significant exercise intolerance despite
the health benefits in exercise. Most children with SCD also miss out on the important benefits
of exercise because of unsubstantiated fears that it might be harmful in their condition. Several
factors could contribute to exercise limitation in these patients. The six-minute walk test
(6MWT) is a standardized test use to measure a person’s exercise tolerance. It is being
increasingly used as a measure of overall functional ability in patients. However little
information exists regarding the safety or the limit of exercise SCD patients can tolerate. The
purpose of the present study is to examine these issues.
To determine the exercise tolerance limit of SCD patients by using the six-minute walk test.
A case control study was performed on 36 adult SCD patients (13 males and 23 females) and
36 healthy adult controls (13 males and 23 females) at the Tema General Hospital by the six
minute walk test (6MWT). Anthropometric data of all participants comprising of height (cm)
and weight (kg) were measured and body mass index (BMI) derived from this data were all
recorded. The haemoglobin (Hb) level of all participants were measured. The following
parameters were measured and recorded in all the participants prior to the 6MWT, 5 and 10
minutes after the test respectively: blood pressure (SBP and DBP), HR, SpO2, PEFR, chest
pain (angina scale), dyspnoea, and leg fatigue (modified Borg scale) The total distance walked
was also recorded in metres. The 6MWD was used to estimate the VO2 and the MET. Factors
associated with the 6MWD were evaluated using multivariate analysis and used to derive an
equation which aimed to estimate the likely 6MWD from the variables. The level of
significance was set at p < 0.05. SPSS version 23 software was used for statistical analysis.
Edu, F (2021). Exercise Tolerance in Adult Sickle Cell Disease Patients. Afribary.com: Retrieved April 10, 2021, from https://afribary.com/works/exercise-tolerance-in-adult-sickle-cell-disease-patients
Frontiers, Edu. "Exercise Tolerance in Adult Sickle Cell Disease Patients" Afribary.com. Afribary.com, 06 Apr. 2021, https://afribary.com/works/exercise-tolerance-in-adult-sickle-cell-disease-patients . Accessed 10 Apr. 2021.
Frontiers, Edu. "Exercise Tolerance in Adult Sickle Cell Disease Patients". Afribary.com, Afribary.com, 06 Apr. 2021. Web. 10 Apr. 2021. < https://afribary.com/works/exercise-tolerance-in-adult-sickle-cell-disease-patients >.
Frontiers, Edu. "Exercise Tolerance in Adult Sickle Cell Disease Patients" Afribary.com (2021). Accessed April 10, 2021. https://afribary.com/works/exercise-tolerance-in-adult-sickle-cell-disease-patients