Research Papers/Topics in Pathology

Serum Leptin And C-Reactive Protein Levels In Obese Ghanaians With And Without Type 2 Diabetes Mellitus At Korle-Bu Teaching Hospital (Kbth), Accra

ABSTRACTThe prevalence of obesity is increasing in Ghana. Obesity is associated with increased risk of many chronic diseases especially type 2 diabetes mellitus. Researching into diagnostic markers is very important. Leptin and C-reactive protein have been implicated in the pathogenesis of diabetes related disorders such as obesity. The aim of this study was to compare serum leptin and C-reactive proteins concentration in obese Ghanaians with and without type 2 diabetes mellitus. Eighty (80) ...

Evaluation Of Antioxidant And Cytotoxic Properties Of Citrullus Lanatus Extracts

ABSTRACT INTRODUCTION Citrullus lanatus (watermelon) is well noted for its nutritional and therapeutic uses. The seeds and mesocarp of the fruit, which were of interest in this study are rich sources of phytochemicals including flavonoids and phenols. These bestow upon the fruit its medicinal properties such as antioxidant, anti-inflammatory, analgesic and anti-hypertensive activities. Cancer has been a public health menace for long and it currently stands as the world’s second killer...

Assessment Of The Viability Of Adult Onchocerca Volvulus In Tissue Sections Using Enzyme Histochemical Demonstration Of Lactate Dehydrogenase Activity

ABSTRACT Current methods of assessing the viability of adult Onchocerca volvulus in drug evaluations are mainly based on in-vitro and histological techniques. The in-vitro method is efficient in detecting live and dead worms while the histological method is more efficient in determining the number of worms in the nodules. Despite their capabilities in some areas, these techniques have certain methodical deficiencies which often lead to inaccurate interpretation of results or marked vari...

Levels Of Adipokines In Ghanaian Women In Jamestown, Accra

ABSTRACT Adipokines are bioactive mediators that communicate between adipose tissue and other biological systems. Adipokines have strongly been linked to adiposity and obesity. The body’s balance of adipokines is fundamental to prevent obesity and other noncommunicable disease. However, their levels in the aetiogenesis of obesity or otherwise have not been studied in Ghana.. The aim of the study was to investigate the levels of plasma Leptin, Adiponectin, Resistin (major adipokin...

Influence Of Religiosity, Sexual Attitudes And Sexual Sensation Seeking On Sociosexuality In Accra, Ghana

ABSTRACT Sociosexuality is a sexual risk behaviour, which poses public health concerns. This study aimed at determining some predictors of sociosexuality among young adults in Accra, Ghana. A sample size of 315 (164 = males, 151 = females) was recruited for this study. Participants completed questionnaires assessing dimensions of sociosexuality (i. e. sociosexual behaviour, sociosexual attitude, and sociosexual desire), sexual sensation seeking, sexual attitudes, dimensions of relig...

Aflatoxin Levels In Adults With Viral Hepatitis Infection In The Ejura-Sekyedumase District Of Ghana

ABSTRACT The consumption of foodstuffs contaminated with aflatoxins may lead to hepatotoxic effect particularly in coexistence with chronic viral hepatitis infection. In Sub-Saharan Africa, hepatocellular carcinoma is one of the most common malignancies. The aim of this study was to measure the level of exposure of aflatoxin and liver damage markers in adults with viral hepatitis in Ghana. The study was conducted in the EjuraSekyedumase district, Ghana. Five hundred adults were scre...

Lipid Peroxidation And Antioxidant Status In Type 2 Diabetes Mellitus In Ghana.

ABSTRACT An imbalance between reactive oxygen species production and antioxidant scavenging has been implicated in type 2 diabetes mellitus. Reports indicate that several complications of diabetes mellitus result from increased activity of free radicals and accumulation of lipid peroxidation products leading to oxidative stress. The study was aimed at evaluating lipid peroxidation and antioxidant status along with lipid profile of type 2 diabetes mellitus patients and age- matched healt...

The Impact Of Regular Exercise On Antioxidants And Selected Biochemical Health Indicators

ABSTRACT Intense exercise alters the production of reactive oxygen species (ROS) and may be an effective means to reduce their deleterious effect on the body. Two major classes of endogenous protective mechanisms work together to reduce the harmful effects of oxidants in the cell. The enzymatic scavenging system such as superoxide dismutase and the nonenzymatic antioxidants such as, albumin and uric acid can reduce ROS and protect tissues against oxidative damage. This oxidant-antioxidan...

Evaluation Of Renal And Hepatic Dysfunction Among Children Less Than Five Years With Malaria In Jasikan District, Oti Region- Ghana

ABSTRACTBackgroundMalaria continues to be a menace in many parts of the world, contributing to high morbidity and mortality especially in developing countries. Irrespective of the immense contributions made to control malaria infection rates, the infection perpetually plagues numerous lives in sub-Saharan Africa. Malaria infection has also been implicated in renal and hepatic dysfunction. The renal dysfunction typifies an increase of urea and creatinine levels in serum whiles the hepatic dysf...

The Association Of Kisspeptin With Polycystic Ovarian Syndrome

ABSTRACT Polycystic ovarian syndrome (PCOS) is a common endocrine abnormality in women of reproductive age which often varies from mild menstrual disorder to severe disturbance of reproductive and metabolic functions. It is characterized by a collection of signs and symptoms which include ovulatory dysfunction-related infertility, menstrual disorders or androgen-related symptoms. Kisspeptin is a 54 amino acid neuropeptide that plays an essential role in human metabolism. It is encoded ...

Studies Of The Antidiabetic Activity And Organspecific Toxicity Of Aqueous Stem Bark Extract Of Annickia Polycarpa

ABSTRACT The antidiabetic effect of aqueous stem bark extract of A. polycarpa (AP) in male ICR mice and its sub-chronic toxicity in Sprague-Dawley rats were investigated. The effect of AP (20 mg/kg, 100 mg/kg, and 500 mg/kg) on fasting blood glucose, serum triglyceride and total cholesterol levels were determined over a period of 4 weeks. An oral glucose tolerance test was also conducted over 150 min post-glucose load. Organ specific toxicity of AP (20 mg/kg, 100 mg/kg, and 500 mg/kg) i...

Antioxidant And Anticancer Potentials Of Natural Cocoa Extract

ABSTRACT In spite of several research efforts and therapeutic interventions, cancer remains a major public health burden across the globe. Cancer treatment is still confronted with challenges including drug resistance and many undesirable side effects. Chemotherapy, the standard cancer treatment is seriously challenged with a lot of shortcomings and hence finding an alternative source of potent anticancer agents is critical to combat the menace. Plant and other natural products have pro...

Serum Leptin Levels Among Chronic Kidney Diseased Subjects With Hypertensive Heart Disease Attending Korle-Bu Teaching Hospital

ABSTRACT Background: Chronic kidney disease (CKD) is a serious public health issue. Leptin, a peptide hormone produced by the adipocytes is very important in the regulation of food and energy. Increased Leptin concentrations are seen in CKD, and have been observed to trigger further complications such as cardiovascular diseases with significant mortality. Despite the interrelationship between leptin and CKD, and their associated adverse health outcomes, the precise role of leptin in hyp...

Aetiology, Importance And Control Of A Vine-Browning And Dieback Disease Of Water Yam (Dioscorea Alata L.) In The Volta Region Of Ghana

ABSTRACT Vine-browning and die-back disease (anthracnose disease) is a major constraint and a predominant disease in all yam producing areas especially, in Africa. The disease reduces photosynthetic area of infected yam plants resulting in severe yield loss. Farmers and Agricultural Extension Agents in the Nkwanta-North and Krachi-West districts of the Volta Region have recently reported high incidence of the disease on their farms. A study was, therefore, conducted from January, 2012 to...

Associiation Between Vitamin D and Renal Function Among Ghanaian HIV/AIDS Patients

A gkcaB r nuo d ehT erp v nela ce of H VI noma g anahG i na y htuo ar ng se morf 4.2 % ot .3 5 .% aM ny d shtae fo H VI stneitap era c desua by c snoitacilpmo ekil laner dna oidrac v ralucsa sid ae .ses dipaR noitacilper of HIV hcihw si derovaf by in rc e desa ox itadi ev st sser dna eht kcatta fo itcaer ev ox evitadi eiceps s )SOR( no eht 4DC + T-c slle era ht e rojam esuac s fo +4DC T- llec ped l noite ni HI /V AI SD p stneita . Effe evitc ucric l nita g oitna x tnadi dna slarenim am ...


1 - 15 Of 19 Results