Virology Research Papers/Topics

High Seroprevalence of Immunoglobulin G (Igg) and 2 Igm Antibodies to SARS-Cov-2 in Asymptomatic and 3 Symptomatic Individuals amidst Vaccination Roll-Out 4 in Western Kenya

Abstract/Overview The population's antibody response is a key factor in comprehending SARS-CoV-2 epidemiology. This is especially important in African settings where COVID-19 impact, and vaccination rates are relatively low. This study aimed at characterizing the Immunoglobulin G (IgG) and Immunoglobulin M (IgM) in both SARS-CoV-2 asymptomatic and symptomatic individuals in Kisumu and Siaya counties in Western Kenya using enzyme linked immunosorbent assays. The IgG and IgM overall seropre...

Neglected tropical diseases: Mathematical modelling and control of within-host and transmission dynamics of viral infections

Abstract: Neglected tropical diseases (NTDs) are a health crisis that is ignored by the developed world and only starts getting attention when there is an outbreak that kills a large population. AIDS associated Kaposi sarcoma (AIDS-KS) and Ebola Virus Disease (EVD) are viral infections which are just two of the many NTDs that require attention. This thesis presents novel within-host ordinary differential equation (ODE) mathematical models in conjunction with application of the optimal contro...

High Rate of non-detectable HIV-1 RnA Among Antiretroviral Drug naive HIV positive Individuals in nigeria

Abstract Plasma HIV-1 RNA concentration, or viral load, is an indication of the magnitude of virus replication and largely correlates with disease progression in an infected person. It is a very useful guide for initiation of therapy and monitoring of response to antiretroviral drugs. Although the majority of patients who are not on antiretroviral therapy (ART) have a high viral load, a small proportion of ART naive patients are known to maintain low levels or even undetectable viral load lev...

Hepatitis E Virus Infection in HIV Positive ART Naïve and Experienced Individuals in Nigeria

ABSTRACT Background: Studies have shown Hepatitis E Virus to be a causative agent of acute and chronic hepatitis in severely immunocompromised patients such as organ transplant recipients and person with HIV infection. This study was de- signed to determine the burden of HEV infection among HIV positive individuals in Nigeria and the effect of HIV treatment on the burden of HEV infection among this group of patients. Methods: Aliquot of plasma samples collected for laboratory investigations...

HW-1 Drug Resistant Mutations In Chronically Infected -Treatment Naive Individuals in The Pre-ARV Era in Nigeria

Abstract In Nigeria the Federal Government rolled out antiretroviral drugs for the management of HW infection in year 2002. This study was carried out to determine the circulating antiviral drug mutations amrmg ARV naive patients with chronic HIV infection durillg the pre-ARV roll out era in &e country. DNA was extracted from scored whole blood samples collected from 75 HlV positive patients attending the Medical outpatient clinic between December 19% and November 2001. The Reverse mscriptas...

Hepatitis Band C Viral Markers In Patietns With Sickle Cell Disease In Ibadan, Nigeria

Summary Serum samples from 180 Sickle Cell Disease (SCD) patients attending Medical Out patients (MOP) clinic of the Department ofHaematology, UCH, lbadan, Nigeria were tested for the presence of HbsAg and anti-HCV in their blood samples. The result showed that HBV infection was slightly higher (not significant) than HCV infection among SCD patients (p>O.05). In addition, the result showed that the mean number of transfusion was higher among patients who were sero-positive for both HbsAg (5.0...

Pattern of HIV-1 Drug Resistance among Adults on ART in Nigeria

ABSTRACT Background: The development of anitiretroviral drug resistance may limit the benefit of antiretroviral therapy. Therefore the need to closely monitor these mutations, especially the use of ART is increasing. This study was therefore designed to determine the ARV drug resistance pattern among ART naïve and expose individuals attending a PEPFAR supported by antiretroviral clinic in Nigeria. Methodology: The study participants included patients attending the PEPFAR supported by Unive...

Suboptimal Etravirine Activity is Common During Failure of Nevirapine Based Combination Antiretroviral Therapy in a Cohort Infected with Non-B Subtype HIV-1

ABSTRACT The primary objective of this study was to estimate etravirine activities in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine based therapy.

Subtype-Specific Patterns in HIV Type 1 Reverse Transcriptase and Protease in Oyo State, Nigeria: Implications for Drug Resistance and Host Response

ABSTRACT As the use of antiretroviral therapy becomes more widespread across Africa, it is imperative to characterise baseline molecular variability and sub-type specific peculiarities of drug targets in non subtype B HIV-1 infection.

Reliability of testing and potential impact of HIV prevention in Nigeria

ABSTRACT Several factors including variability of human immunodeficiency virus (HIV), Laboratory facilities, cost and competence of personnel handling the test are some of the important factors that affect accuracy and reliability of HIV testing in most part of Africa.

Prevalence of HIV-1 Subtypes in Infected Concordant and Discordant Couples in Nigeria

ABSTRACT The peptide binding immunoassay [PELISA) was used as previously described to determine HIV-1 subtypes among 60 married HIV-1 seropositive individuals and their spouses identified at the University College Hospital, lbadan in order to investigate the rate of heterosexual partners by different HIV-1 subtypes in Nigeria. 

Human immunodeficiency serpositivity among mother-child pairs in South West Nigeria: A community based survey

ABSTRACT A community based survey to determine the prevalence human immunodeficiency infection in Nigeria women and children in South Western Nigeria is reported.

HIV infection among patients with pulmonary tuberculosis in Nigeria

ABSTRACT Respiratory problems like pneumocystic carinni and pulmonary tuberculosis are among the common opportunistic infections in patients with HIV/AIDS.

HCV and HBV Infections in Nigerian Patients with Liver Cirrhosis and Hepatocellular Carcinoma

ABSTRACT Although efforts have been made to determine the significance of Hepatitis B virus infection in Nigerians with chronic liver disease.

An Improved PCR Method for Detection of HIV-1 proviral DNA of a Wide Range of Subtypes and Recombinant Forms Circulating Globally

ABSTRACT Proviral DNAs are being measured increasingly as a marker of efficacy of highly active retroviral therapy and is accepted for the early diagnosis of perinatal HIV-1 treatments.

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