Research Papers/Topics in Virology

Hepatitis Band C Viral Markers In Patietns With Sickle Cell Disease In Ibadan, Nigeria

Summary Serum samples from 180 Sickle Cell Disease (SCD) patients attending Medical Out patients (MOP) clinic of the Department ofHaematology, UCH, lbadan, Nigeria were tested for the presence of HbsAg and anti-HCV in their blood samples. The result showed that HBV infection was slightly higher (not significant) than HCV infection among SCD patients (p>O.05). In addition, the result showed that the mean number of transfusion was higher among patients who were sero-positive for both HbsAg...

Pattern of HIV-1 Drug Resistance among Adults on ART in Nigeria

ABSTRACT Background: The development of anitiretroviral drug resistance may limit the benefit of antiretroviral therapy. Therefore the need to closely monitor these mutations, especially the use of ART is increasing. This study was therefore designed to determine the ARV drug resistance pattern among ART naïve and expose individuals attending a PEPFAR supported by antiretroviral clinic in Nigeria. Methodology: The study participants included patients attending the PEPFAR supported by Univ...

Suboptimal Etravirine Activity is Common During Failure of Nevirapine Based Combination Antiretroviral Therapy in a Cohort Infected with Non-B Subtype HIV-1

ABSTRACTThe primary objective of this study was to estimate etravirine activities in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine based therapy.

Subtype-Specific Patterns in HIV Type 1 Reverse Transcriptase and Protease in Oyo State, Nigeria: Implications for Drug Resistance and Host Response

ABSTRACTAs the use of antiretroviral therapy becomes more widespread across Africa, it is imperative to characterise baseline molecular variability and sub-type specific peculiarities of drug targets in non subtype B HIV-1 infection.

Reliability of testing and potential impact of HIV prevention in Nigeria

ABSTRACTSeveral factors including variability of human immunodeficiency virus (HIV), Laboratory facilities, cost and competence of personnel handling the test are some of the important factors that affect accuracy and reliability of HIV testing in most part of Africa.

Prevalence of HIV-1 Subtypes in Infected Concordant and Discordant Couples in Nigeria

ABSTRACTThe peptide binding immunoassay [PELISA) was used as previously described to determine HIV-1 subtypes among 60 married HIV-1 seropositive individuals and their spouses identified at the University College Hospital, lbadan in order to investigate the rate of heterosexual partners by different HIV-1 subtypes in Nigeria. 

Human immunodeficiency serpositivity among mother-child pairs in South West Nigeria: A community based survey

ABSTRACTA community based survey to determine the prevalence human immunodeficiency infection in Nigeria women and children in South Western Nigeria is reported.

HIV infection among patients with pulmonary tuberculosis in Nigeria

ABSTRACTRespiratory problems like pneumocystic carinni and pulmonary tuberculosis are among the common opportunistic infections in patients with HIV/AIDS.

HCV and HBV Infections in Nigerian Patients with Liver Cirrhosis and Hepatocellular Carcinoma

ABSTRACTAlthough efforts have been made to determine the significance of Hepatitis B virus infection in Nigerians with chronic liver disease.

An Improved PCR Method for Detection of HIV-1 proviral DNA of a Wide Range of Subtypes and Recombinant Forms Circulating Globally

ABSTRACTProviral DNAs are being measured increasingly as a marker of efficacy of highly active retroviral therapy and is accepted for the early diagnosis of perinatal HIV-1 treatments.

HIV Infection among Newly Diagnosed TB Patients in Southwestern Nigeria: A Multi-DOTS Center Study

ABSTRACT Backgroud: The burden of TB and HIV infection is estimated to be about 512/100,000 and 3,000,000 people respectively. However, accurate data on TB/HIV co-morbidity in different parts of Nigeria were not available due to limited access to HIV Counseling and Testing (HCT) by individuals with TB infection. This study was designed to determine the true rate of HIV infection among newly diagnosed TB patients by providing comprehensive HCT services in 43 DOTS centers in Oyo State, Sout...

THE VIROLOGY AND DYNAMICS OF THE EPIDEMIC

ABSTRACTViruses are submicroscopic, obligate intracellular parasites that can neither grow nor reproduce outside a living cell. Their survival therefore depends completely on the continued survival of their hosts.

Demographic and Laboratory Evidence of Non Sexual Transmission of HIV in Nigeria

ABSTRACTApart from heterosexual transmission, not much is known about the contribution of the other modes of spread of HIV in Africa. To evaluate the importance of non-sexual/non-vertical transmission in adults and children in Nigeria, data from mother-child pairs (community and hospital) and a community HIV surveillance among adult populations in two communities of Oyo State in S1¥ Nigeria were' analysed. In the community-based mother-child pair HIV testing, 18 of 476 (3.8%) under 5 y...

INCIDENCE OF HEPATITIS C VIRUS INFECTION IN A SEMIURBAN COMMUNITY OF SOUTHWESTERN NIGERIA

ABSTRACT Hepatitis C Virus (HCV) infection is an important cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Its epidemiology has been well described in developed countries. In Nigeria, previous studies on the virus were hospital-based or point prevalence from which the burden of HCV cannot be accurately determined. A population-based prospective study was therefore designed to assess the burden of HCV infection in a semi-urban community in southwestern Nigeria. A coho...

Hepatitis B Virus DNA in Patients With HBsAg in South Western Nigeria

ABSTRACTThere are about 400 million people with chronic hepatitis b  virus (HBV) infection worldwide with a potential of adverse sequelas including hepatocellular carcinoma. Recent data have shown that the level of HBV DNA in serum or plasma of an infected person probably reflects more accurately the replicative activity of the virus and therefore may serve as a better maker for management of the infection. This study was designed to determine the rate of detection of HBV DNA i...


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