Abstract: We have previously described a method to predict antigenic epitopes on proteins recognized by specific antibodies. Here we have applied this method to identify epitopes on the NS1 proteins of the four Dengue virus serotypes (DENV1–4) that are bound by a small panel of monoclonal antibodies 1H7.4, 1G5.3 and Gus2. Several epitope regions were predicted for these antibodies and these were found to reflect the experimentally observed reactivities. The known binding epitopes on DENV2 ...
We are pleased to see the three follow- up letters concerning our “World Scientists’ Warning to Humanity: A Second Notice” (Ripple et al. 2017). Each letter expresses a thoughtful, heartfelt response to our paper. We agree in how they describe the need to get more scientists into policymaking positions (Dror), to create a new global environmental ethic (Skubała), and to recognize economic growth as a major driver of environmental impacts (Pacheco et al.). The letters rais...