ABSTRACT African trypanosomiasis is a disease caused by the parasitic protozoans of African trypanosomes. Despite several efforts at chemotherapeutic interventions, the disease poses serious health and economic concerns to humans and animals of various sub-Saharan African countries. Commercially available drugs such as suramin, eflornithine, pentamidine, melarsoprol and nifurtimox have reported cases of undesirable side effects, drug resistance, and difficulty in regimen application. Studies ...
Abstract Malaria pathogenesis is an intricate process mediated by factors found in both the host and the parasite. The adaptive immune response to the most lethal malaria parasite, Plasmodium falciparum, remains to be fully comprehended. Meanwhile, T cells, which are critical for the host responses interact with antigens coupled with MHC molecules, through their membrane surface-expressed T cell receptor (TCR). These TCRs are produced by a process of imprecise gene rearrangement called V(D)J ...
ABSTRACT Avocado (Persia americana Mill) is a nutritious economic tree crop with cultivations scattered all over the country. A study was conducted to assess its distribution, uses and the morphological and genetic diversity of the crop in the Ashanti and Central Regions of Ghana. An ethnobotanical survey was carried out in 14 districts, while morphological and genetic diversities were determined among the accessions in eight districts. Microsatellites markers were used for genetic diversity...
ABSTRACT Tuberculosis (TB) still remains a major global health problem particularly in resourcelimited settings despite the availability of treatment regimen for decades. Although two pathogens, Mycobacterium tuberculosis sensu stricto (MTBss) and Mycobacterium africanum (Maf) are responsible for TB incidence in humans, more research attention has been accorded MTBss to the neglect of Maf, which is reported to be geographically restricted to West Africa and its immigrants. This thesis s...
ABSTRACT Group A Rotaviruses (RVAs) are the most important etiological agents of acute gastroenteritis (AGE) in children less than 5 years of age. Mortality resulting from RVA gastroenteritis is higher in developing countries than in developed ones, causing a huge public health burden in global regions like Africa and South East Asia. The aim of this study was to investigate the strains of RVAs causing AGE in children less than 5 years of age in Ashaiman after the introduction of the Rot...