Abstract A common molecular variant of the angiotensinogen gene had been reported to predispose some ethnic groups to hypertension. This case-control study was designed to determine the frequency and association of the angiotensinogen M235T al1ele with hypertension in residents of Calabar and Uyo cities, south-south Nigeria. The study involved 1308 subjects, 612 patients and 696 controls. The M235T variant was investigated using an allele specific polymerase chain reaction and enzymatic diges...