ABSTRACT
Experiences of early antiretroviral treatment failures are increasingly linked to escalating pretherapy HIV resistance mutations. Regular update of epidemic status and impact of pretherapy resistance are needed in resource limited countries, including Kenya. Since pretherapy resistance survey has not been conducted and factors associated remain unknown in the high-HIV prevalence western Kenya region, this study aimed to establish the prevalence of pretherapy antiretroviral resistance, the associated factors, the mutations’ impact on treatment, the HIV subtypes and phylogenetic relationships in the major urban establishment of Kisumu. Two hundred and forty HIV-1 infected persons were consecutively recruited and followed-up for 12 months at 2 facilities between 2013 through to 2015. Blood samples along with demographic information were obtained at both study baseline and follow-up end-point. Genetic sequence analysis of partial pol gene was performed on all baseline, and the end-point samples that had viral RNA≥1000 copies/mL. Calibrated Population Resistance tool and Drug Resistance Database algorithms for HIV were used in the interpretation of baseline and end-point resistance mutations respectively. Subtyping was performed using REGA v3.0, RIP v3.0 and in addition phylogenetic relationship analysis was performed using MEGA 6.0. Prevalence were calculated in percentages, categorical variables compared by x2 and fisher’s exact test while continuous variables were compared by Mann-Whitney U test. Factors that had p
OMONDI, O (2021). Genetic Characterization Of Antiretroviral Resistance And Their Effect On Human Immunodeficiency Virus Infected Patients Initiating Therapy In Kisumu -Kenya. Afribary. Retrieved from https://afribary.com/works/genetic-characterization-of-antiretroviral-resistance-and-their-effect-on-human-immunodeficiency-virus-infected-patients-initiating-therapy-in-kisumu-kenya
OMONDI, OWITI "Genetic Characterization Of Antiretroviral Resistance And Their Effect On Human Immunodeficiency Virus Infected Patients Initiating Therapy In Kisumu -Kenya" Afribary. Afribary, 06 May. 2021, https://afribary.com/works/genetic-characterization-of-antiretroviral-resistance-and-their-effect-on-human-immunodeficiency-virus-infected-patients-initiating-therapy-in-kisumu-kenya. Accessed 20 Apr. 2024.
OMONDI, OWITI . "Genetic Characterization Of Antiretroviral Resistance And Their Effect On Human Immunodeficiency Virus Infected Patients Initiating Therapy In Kisumu -Kenya". Afribary, Afribary, 06 May. 2021. Web. 20 Apr. 2024. < https://afribary.com/works/genetic-characterization-of-antiretroviral-resistance-and-their-effect-on-human-immunodeficiency-virus-infected-patients-initiating-therapy-in-kisumu-kenya >.
OMONDI, OWITI . "Genetic Characterization Of Antiretroviral Resistance And Their Effect On Human Immunodeficiency Virus Infected Patients Initiating Therapy In Kisumu -Kenya" Afribary (2021). Accessed April 20, 2024. https://afribary.com/works/genetic-characterization-of-antiretroviral-resistance-and-their-effect-on-human-immunodeficiency-virus-infected-patients-initiating-therapy-in-kisumu-kenya