Introduction: Ethanol is one of the hepatotoxic substances that cause various hepato-degenerative
disorders which is a major concern in medical science and researches as man is regularly exposed
to it via consumption.
Methods: The aim of this study is to investigate and compare the protective effects of livolin forte
with methanolic extract of Vernonia amygdalina on the hepatic cells of ethanol induced
hepatotoxicity, 25 healthy male Wistar rats weight ranging between 150-200g were allotted into 5
groups: Normal control (Group A), ethanol control (B), combine therapy control (Group C), Livolin
forte control (Group D), and Vernonia amygdalina control (Group E) of five animals each.
Results: The macroscopic change such as nodular and abscesses were observed on the liver of
experimental animals (B, C, D and D) with regenerating changes in groups C, D and E. while the
liver architecture for the control animals appeal normal. Toxicant group B had significant higher
AST, ALT and ALP compared with the normal control group A. Similar, significant increase in serum
activities of AST, ALT and ALP were observed in group D&E compare to group C.
Conclusion: The result of this study indicated that livolin forte was better combine with Vernonia
amygdalina as a curative agent rather than livolin forte or Vernonia amygdalina alone in Rats
model.
Keywords: Hepatotoxicity; Vernonia amygdalina; alanine-aminotransferase (ALT); aspartate
aminotransferase (AST); alkaline- phosphates (ALP
Olatoye, A., Olatoye, A , Olayemi, O & Olatoye, A (2022). Histological comparative studies of Vernonia amygdalina and standard livolin forte on ethanol induced hepatotoxicity in adult wistar rat. Afribary. Retrieved from https://afribary.com/works/histological-comparative-studies-of-vernonia-amygdalina-and-standard-livolin-forte-on-ethanol-induced-hepatotoxicity-in-adult-wistar-rat
Olatoye, Adeniyi Micheal, et. al. "Histological comparative studies of Vernonia amygdalina and standard livolin forte on ethanol induced hepatotoxicity in adult wistar rat" Afribary. Afribary, 07 Oct. 2022, https://afribary.com/works/histological-comparative-studies-of-vernonia-amygdalina-and-standard-livolin-forte-on-ethanol-induced-hepatotoxicity-in-adult-wistar-rat. Accessed 27 Apr. 2024.
Olatoye, Adeniyi Micheal, Adeniyi Olatoye , Olaniyi Olayemi and Adesola Olatoye . "Histological comparative studies of Vernonia amygdalina and standard livolin forte on ethanol induced hepatotoxicity in adult wistar rat". Afribary, Afribary, 07 Oct. 2022. Web. 27 Apr. 2024. < https://afribary.com/works/histological-comparative-studies-of-vernonia-amygdalina-and-standard-livolin-forte-on-ethanol-induced-hepatotoxicity-in-adult-wistar-rat >.
Olatoye, Adeniyi Micheal, Adeniyi Olatoye , Olaniyi Olayemi and Adesola Olatoye . "Histological comparative studies of Vernonia amygdalina and standard livolin forte on ethanol induced hepatotoxicity in adult wistar rat" Afribary (2022). Accessed April 27, 2024. https://afribary.com/works/histological-comparative-studies-of-vernonia-amygdalina-and-standard-livolin-forte-on-ethanol-induced-hepatotoxicity-in-adult-wistar-rat