ABSTRACT
The aim was to investigate the effect of Sphenocentrum jollyanum (SJ) extract on alloxan-induced diabetic and hyperglycaemic rabbits. The prophylactic effect and the hypoglycaemic activity of SJ extracts were equally evaluated. Other biochemical parameters evaluated included lipid profile. The acute and chronic toxicity tests were also conducted to ascertain the plant's toxicity level.
In diabetic study, alloxan diabetic rabbits were treated with graded doses of SJ at 50, 100 and 200 mg/kg for the root and leaf extracts and 300, 600 and 1200 mg/kg for the seed extract or 10 mg/kg of glibenclamide. Blood was collected at days 0,3, 5, 7, 9, 11, 13 and 15 and analyzed. The effects of the extract on oral glucose loaded rabbits were also evaluated. In prophylactic study, animals received oral treatment as follows: group A and B received only distilled water; group C, glibenclamide (10 mg/kg); group D, root extract (100 mg/kg); group E, leaf extract (100 mg/kg); group F, seed extract (600 mg/kg). A 1 week later (day 0), basal glycaemia was determined followed by alloxan challenge (170mg/kg). Blood collection and analysis was described in diabetic study.
OYEBUEKE, M (2021). Histomophological And Biochemical Studies On Alloxan-Induce Diabetic Rabbits Treated With Sphenocentrum Jollyanum Menispermceae (Pierre). Afribary. Retrieved from https://afribary.com/works/histomophological-and-biochemical-studies-on-alloxan-induce-diabetic-rabbits-treated-with-sphenocentrum-jollyanum-menispermceae-pierre
OYEBUEKE, MBAKA "Histomophological And Biochemical Studies On Alloxan-Induce Diabetic Rabbits Treated With Sphenocentrum Jollyanum Menispermceae (Pierre)" Afribary. Afribary, 08 May. 2021, https://afribary.com/works/histomophological-and-biochemical-studies-on-alloxan-induce-diabetic-rabbits-treated-with-sphenocentrum-jollyanum-menispermceae-pierre. Accessed 25 Apr. 2024.
OYEBUEKE, MBAKA . "Histomophological And Biochemical Studies On Alloxan-Induce Diabetic Rabbits Treated With Sphenocentrum Jollyanum Menispermceae (Pierre)". Afribary, Afribary, 08 May. 2021. Web. 25 Apr. 2024. < https://afribary.com/works/histomophological-and-biochemical-studies-on-alloxan-induce-diabetic-rabbits-treated-with-sphenocentrum-jollyanum-menispermceae-pierre >.
OYEBUEKE, MBAKA . "Histomophological And Biochemical Studies On Alloxan-Induce Diabetic Rabbits Treated With Sphenocentrum Jollyanum Menispermceae (Pierre)" Afribary (2021). Accessed April 25, 2024. https://afribary.com/works/histomophological-and-biochemical-studies-on-alloxan-induce-diabetic-rabbits-treated-with-sphenocentrum-jollyanum-menispermceae-pierre