Abstract:
Background: Majority of people opt the use of traditional means of treatment especially medicinal plants on the notion of being safe since they are naturally derived.
Objective: The study aimed at evaluation of the antidiabetic efficacy of extract and fraction and safety profile of Solanum terminale fruits extract in mice.
Methods: Mice were induced diabetes by intraperitoneal injection of freshly prepared alloxan monohydrate 170 mg/kg BW.The diabetic mice were treated once daily with crude extract and methanol fraction (100 mg/kg BW) for 20 days, and FBG were recorded on day 1, 5, 10, 15 and 20. The effects of the extract and fraction on FBG levels of the diabetic mice were evaluated. OECD guidelines were used in assessing the acute oral toxicity of S. terminale fruits extract by single dose of crude extract at 2000 mg/kg BW. Mice were observed for 14 days for their mortality, behavioral and other changes. Before sacrifice, weight of mice and the visceral organs were recorded, and sent for histological evaluations. Results were expressed as mean ± SD, analysed by independent student’s t-test, p
Kingo1, R & , 2 (2021). In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae). Afribary. Retrieved from https://afribary.com/works/in-vivo-antidiabetic-activity-and-safety-profile-of-fruits-extract-and-fraction-of-solanum-terminale-forsk-solanaceae
Kingo1, Rajabu and 2 "In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)" Afribary. Afribary, 26 Apr. 2021, https://afribary.com/works/in-vivo-antidiabetic-activity-and-safety-profile-of-fruits-extract-and-fraction-of-solanum-terminale-forsk-solanaceae. Accessed 05 May. 2024.
Kingo1, Rajabu, 2 . "In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)". Afribary, Afribary, 26 Apr. 2021. Web. 05 May. 2024. < https://afribary.com/works/in-vivo-antidiabetic-activity-and-safety-profile-of-fruits-extract-and-fraction-of-solanum-terminale-forsk-solanaceae >.
Kingo1, Rajabu and , 2 . "In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)" Afribary (2021). Accessed May 05, 2024. https://afribary.com/works/in-vivo-antidiabetic-activity-and-safety-profile-of-fruits-extract-and-fraction-of-solanum-terminale-forsk-solanaceae