ABSTRACT
Halloysite, a natural mineral mined in many parts of the world has gained a lot of
attention recently due to its ability to control and sustain the release of drugs and other
active agents. It is a hollow tubular structure composed of double layer of aluminosilicate
minerals in the nanometric range. They are non-toxic and biocompatible as compared to
other nanocarriers. Its unique structure can be modified to improve its properties for
control drug delivery applications.
In this study, halloysite nanotubes were modified and the effect of these modifications on
sustain drug release was analyzed and evaluated. The two modification techniques
employed were acid-treatment and polymer/ halloysite composite formation. After each
modification, sodium salicylate drug was loaded and their in vitro release properties were
evaluated and compared with raw unmodified halloysite nanotubes. The results obtained
indicate that both acid treatment and polymer/halloysite composite formation have no
effect on the tubular structure and morphology of halloysite. This was shown by SEM,
TEM and FTIR analysis made. However, modification of the halloysite nanotubes
influenced the drug release rate. Results obtained also indicate that in acid–treatment
modification, there was an improved loading of sodium salicylate drug which resulted in
the sustain release of large amount of the sodium salicylate drugs loaded. In
polymer/halloysite composite formation, a consistent layer of polymer formed around the
halloysite during the composite formation and thus delayed and sustained the release of
sodium salicylate drug over a longer period of time as compared to the acid treated and
raw untreated halloysite. In both modifications, the in vitro release was best fit with
v
Higuchi model. However, raw untreated halloysite was best fit with Koresymer-Peppas
model.
BEDIAKO, E (2021). Modified Halloysite Nanotubes As Vehicle For Sustained Drug Delivery. Afribary. Retrieved from https://afribary.com/works/modified-halloysite-nanotubes-as-vehicle-for-sustained-drug-delivery
BEDIAKO, ERNEST "Modified Halloysite Nanotubes As Vehicle For Sustained Drug Delivery" Afribary. Afribary, 19 Apr. 2021, https://afribary.com/works/modified-halloysite-nanotubes-as-vehicle-for-sustained-drug-delivery. Accessed 13 Nov. 2024.
BEDIAKO, ERNEST . "Modified Halloysite Nanotubes As Vehicle For Sustained Drug Delivery". Afribary, Afribary, 19 Apr. 2021. Web. 13 Nov. 2024. < https://afribary.com/works/modified-halloysite-nanotubes-as-vehicle-for-sustained-drug-delivery >.
BEDIAKO, ERNEST . "Modified Halloysite Nanotubes As Vehicle For Sustained Drug Delivery" Afribary (2021). Accessed November 13, 2024. https://afribary.com/works/modified-halloysite-nanotubes-as-vehicle-for-sustained-drug-delivery