Prevalence And Factors Associated With Renal Dysfunction Among Children With Sickle Cell Disease Attending The Sickle Cell Disease Clinic At A Tertiary Hospital In Northwestern Tanzania

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Abstract

Background Little is known on how the interaction between Sickle Cell Disease (SCD) and renal insults caused by other coexisting conditions in Sub Saharan Africa such as urinary schistosomiasis, malnutrition and HIV affect the prevalence of renal dysfunction in children with SCD. Objectives To determine the prevalence and factors associated with renal dysfunction among children with SCD aged 6 months to 12 years attended at a tertiary hospital in Northwestern Tanzania. Methods A cross sectional hospital-based study with a short follow up component of 3 months for 153 children with SCD was done to document demographics, clinical characteristics and features of renal dysfunction including urine dipstick albuminuria (>20mg/l) and eGFR (<60ml/ ml/min/1.73m2 ). Other potential renal insults such as HIV infection and Schistosomiasis were also evaluated. Results At enrollment, 48/153(31.37%) children had renal dysfunction declining to 31(20.3%) at 3 months follow up. Acute chest syndrome (OR 3.04, 95% CI [1.08–8.96], p = 0.044), severe anemia (OR 0.44, 95% CI [0.26–0.76],p = 0.003), urinary schistosomiasis (OR 7.43, 95% CI [2.10–26.32] p<0.002) and acute malnutrition (OR 4.92, 95% CI [1.29–18.84], p = 0.020). were associated with renal dysfunction.

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APA

Edu, F (2021). Prevalence And Factors Associated With Renal Dysfunction Among Children With Sickle Cell Disease Attending The Sickle Cell Disease Clinic At A Tertiary Hospital In Northwestern Tanzania. Afribary.com: Retrieved May 10, 2021, from https://afribary.com/works/prevalence-and-factors-associated-with-renal-dysfunction-among-children-with-sickle-cell-disease-attending-the-sickle-cell-disease-clinic-at-a-tertiary-hospital-in-northwestern-tanzania

MLA 8th

Frontiers, Edu. "Prevalence And Factors Associated With Renal Dysfunction Among Children With Sickle Cell Disease Attending The Sickle Cell Disease Clinic At A Tertiary Hospital In Northwestern Tanzania" Afribary.com. Afribary.com, 01 May. 2021, https://afribary.com/works/prevalence-and-factors-associated-with-renal-dysfunction-among-children-with-sickle-cell-disease-attending-the-sickle-cell-disease-clinic-at-a-tertiary-hospital-in-northwestern-tanzania . Accessed 10 May. 2021.

MLA7

Frontiers, Edu. "Prevalence And Factors Associated With Renal Dysfunction Among Children With Sickle Cell Disease Attending The Sickle Cell Disease Clinic At A Tertiary Hospital In Northwestern Tanzania". Afribary.com, Afribary.com, 01 May. 2021. Web. 10 May. 2021. < https://afribary.com/works/prevalence-and-factors-associated-with-renal-dysfunction-among-children-with-sickle-cell-disease-attending-the-sickle-cell-disease-clinic-at-a-tertiary-hospital-in-northwestern-tanzania >.

Chicago

Frontiers, Edu. "Prevalence And Factors Associated With Renal Dysfunction Among Children With Sickle Cell Disease Attending The Sickle Cell Disease Clinic At A Tertiary Hospital In Northwestern Tanzania" Afribary.com (2021). Accessed May 10, 2021. https://afribary.com/works/prevalence-and-factors-associated-with-renal-dysfunction-among-children-with-sickle-cell-disease-attending-the-sickle-cell-disease-clinic-at-a-tertiary-hospital-in-northwestern-tanzania