ABSTRACT
The synthesis of ten new alkynylated derivatives of angular phenoxazine and alkynylated
naphthoquinone was thoroughly investigated. The first intermediate, 6-chloro-5Hbenzo[
a]phenoxazin-5-one was obtained by the condensation of 2-aminophenol with 2,3-
dichloro-1,4- naphthoquinone in the presence of anhydrous sodium tricarbonate (IV) .
Thereafter, the intermediate and 2,3-dichloro-1,4-naphthoquinone were each suggested to
Sonogashira cross–coupling reaction under copper-, amine-, and solvent free conditions at 80
oC with five different terminal alkynes using PdCL2(PPh3)2 and tetrabutylammonium
trihydrate (TBAF.3H2O) as the catalyst and ligand respectively to afford the alkynylated
angular phenoxazines and alkynylated naphthoquinone derivatives in good to excellent yield .
Structures of synthesized compounds were confirmed with Uv-visible, Fourier Transform –
Infrared (FT-IR), 1H-NMR and 13C-NMR spectroscopy. The synthesized compounds were
screened against five (5) micro-organisms viz: Staphylococcus aureus, Pseudomonas
aeruginosa, Klebsiella pneumonia, Escherichia coli 1 and Escherichia coli 12 using agar
well diffusion technique. The results showed significant improvement in antimicrobial
activities compared with gentamycin and ampicillin (standard drugs).
OLUCHUKWU, U (2021). Syntheses, Characterization And Antimicrobial Activities Of Alkynylated Angular Phenoxazines And Alkynylated Naphthoquinones. Afribary. Retrieved from https://afribary.com/works/syntheses-characterization-and-antimicrobial-activities-of-alkynylated-angular-phenoxazines-and-alkynylated-naphthoquinones-1
OLUCHUKWU, UGWUONA "Syntheses, Characterization And Antimicrobial Activities Of Alkynylated Angular Phenoxazines And Alkynylated Naphthoquinones" Afribary. Afribary, 20 May. 2021, https://afribary.com/works/syntheses-characterization-and-antimicrobial-activities-of-alkynylated-angular-phenoxazines-and-alkynylated-naphthoquinones-1. Accessed 29 Nov. 2024.
OLUCHUKWU, UGWUONA . "Syntheses, Characterization And Antimicrobial Activities Of Alkynylated Angular Phenoxazines And Alkynylated Naphthoquinones". Afribary, Afribary, 20 May. 2021. Web. 29 Nov. 2024. < https://afribary.com/works/syntheses-characterization-and-antimicrobial-activities-of-alkynylated-angular-phenoxazines-and-alkynylated-naphthoquinones-1 >.
OLUCHUKWU, UGWUONA . "Syntheses, Characterization And Antimicrobial Activities Of Alkynylated Angular Phenoxazines And Alkynylated Naphthoquinones" Afribary (2021). Accessed November 29, 2024. https://afribary.com/works/syntheses-characterization-and-antimicrobial-activities-of-alkynylated-angular-phenoxazines-and-alkynylated-naphthoquinones-1