ABSTRACT
The syntheses of benzothiazinophenothiazine derivatives from simple heterocyclic compounds as
precursors is described. Condensation of 2-aminothiophenol with 2,3-dichloro-1,4-naphthoquinone in
an alkaline medium furnished a good yield of the intermediate, 6-chloro-5H-benzo[a]phenothiazin-5-
one. Further condensation of the intermediate with 2,4-diamino-6-hydroxypyrimidine-5-thiol
obtained by alkaline hydrolysis of 2,4-diamino-6-hydroxy-5-thiacyanatopyrimidine gave the
benzothiazinophenothiazine ring system. On the other hand, using a facile acid-catalyzed method, the
synthesis of some benzothiazinophenothiazine ring systems were achieved with improved yield and
lesser reaction time. Structures of the compounds were characterized using UV/Visible
spectrophotometry, fourier transform infra red, 1HNMR and 13CNMR spectroscopies and elemental
analysis. The antimicrobial properties of the synthesized compounds were determined against
Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli,
Klebsiella pneumoniae, Candida albican and Aspergillus niger using agar diffusion technique.
Results showed that the complex derivatives were significantly active against the microorganisms.
EMMANUEL, A (2021). Syntheses Of Benzothiazinophenothiazine Derivatives And Evaluation Of Their Antimicrobial Activities. Afribary. Retrieved from https://afribary.com/works/syntheses-of-benzothiazinophenothiazine-derivatives-and-evaluation-of-their-antimicrobial-activities
EMMANUEL, ADEKOLA "Syntheses Of Benzothiazinophenothiazine Derivatives And Evaluation Of Their Antimicrobial Activities" Afribary. Afribary, 15 May. 2021, https://afribary.com/works/syntheses-of-benzothiazinophenothiazine-derivatives-and-evaluation-of-their-antimicrobial-activities. Accessed 23 Nov. 2024.
EMMANUEL, ADEKOLA . "Syntheses Of Benzothiazinophenothiazine Derivatives And Evaluation Of Their Antimicrobial Activities". Afribary, Afribary, 15 May. 2021. Web. 23 Nov. 2024. < https://afribary.com/works/syntheses-of-benzothiazinophenothiazine-derivatives-and-evaluation-of-their-antimicrobial-activities >.
EMMANUEL, ADEKOLA . "Syntheses Of Benzothiazinophenothiazine Derivatives And Evaluation Of Their Antimicrobial Activities" Afribary (2021). Accessed November 23, 2024. https://afribary.com/works/syntheses-of-benzothiazinophenothiazine-derivatives-and-evaluation-of-their-antimicrobial-activities