ABSTRACT Tandem amidation catalyzed synthesis of linear diazaphenoxazine carboxamide derivatives is reported. This was achieved by the reaction of 2-amino-3-hydroxypyridine and 2,3,5-trichloropyridine in aqueous basic medium which gave 3-chloro-1,9-diazaphenoxazine as white solid crystals. 3-Chloro-1,9-diazaphenoxazine was then subjected to Buchwald-Hartwig amidation coupling reaction with various amides namely formamide, phthalamide, 4- nitrobenzamide, benzamide and acetamide via water promoted catalyst preactivation protocol to afford the following, 3-amido derivatives of 1,9-diazaphenoxazine namely 3-formamido-1,9-diazaphenoxazine, 3- phthalamido-1,9-diazaphenoxazine, 3-(4-nitrobenamido)-1,9-diazaphenoxazine, 3-benzamido-1,9- diazaphenoxazine and 3-acetamido-1,9-diazaphenoxazine. The compounds were characterized using UV-visible, FTIR, 1 HNMR and 13CNMR spectroscopy.
LORRITTA, E (2022). Tandem Amidation Catalysis in the Synthesis of Diazaphenoxazine Carboxamides of Pharmaceutical Interest. Afribary. Retrieved from https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazine-carboxamides-of-pharmaceutical-interest
LORRITTA, EDOKA "Tandem Amidation Catalysis in the Synthesis of Diazaphenoxazine Carboxamides of Pharmaceutical Interest" Afribary. Afribary, 16 Oct. 2022, https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazine-carboxamides-of-pharmaceutical-interest. Accessed 22 Dec. 2024.
LORRITTA, EDOKA . "Tandem Amidation Catalysis in the Synthesis of Diazaphenoxazine Carboxamides of Pharmaceutical Interest". Afribary, Afribary, 16 Oct. 2022. Web. 22 Dec. 2024. < https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazine-carboxamides-of-pharmaceutical-interest >.
LORRITTA, EDOKA . "Tandem Amidation Catalysis in the Synthesis of Diazaphenoxazine Carboxamides of Pharmaceutical Interest" Afribary (2022). Accessed December 22, 2024. https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazine-carboxamides-of-pharmaceutical-interest