ABSTRACT
Tandem amidation catalyzed synthesis of linear diazaphenoxazine carboxamide derivatives is reported. This was
achieved by the reaction of 2-amino-3-hydroxypyridine and 2,3,5-trichloropyridine in aqueous basic medium which
gave 3-chloro-1,9-diazaphenoxazine as white solid crystals. 3-Chloro-1,9-diazaphenoxazine was then subjected to
Buchwald-Hartwig amidation coupling reaction with various amides namely formamide, phthalamide, 4-
nitrobenzamide, benzamide and acetamide via water promoted catalyst preactivation protocol to afford the
following, 3-amido derivatives of 1,9-diazaphenoxazine namely 3-formamido-1,9-diazaphenoxazine, 3-
phthalamido-1,9-diazaphenoxazine, 3-(4-nitrobenamido)-1,9-diazaphenoxazine, 3-benzamido-1,9-
diazaphenoxazine and 3-acetamido-1,9-diazaphenoxazine. The compounds were characterized using UV-visible,
FTIR, 1HNMR and 13CNMR spectroscopy.
LORRITTA, E (2021). Tandem Amidation Catalysis In The Synthesis Of Diazaphenoxazinecarboxamides Of Pharmaceutical Interest. Afribary. Retrieved from https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazinecarboxamides-of-pharmaceutical-interest
LORRITTA, EDOKA "Tandem Amidation Catalysis In The Synthesis Of Diazaphenoxazinecarboxamides Of Pharmaceutical Interest" Afribary. Afribary, 20 May. 2021, https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazinecarboxamides-of-pharmaceutical-interest. Accessed 01 May. 2024.
LORRITTA, EDOKA . "Tandem Amidation Catalysis In The Synthesis Of Diazaphenoxazinecarboxamides Of Pharmaceutical Interest". Afribary, Afribary, 20 May. 2021. Web. 01 May. 2024. < https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazinecarboxamides-of-pharmaceutical-interest >.
LORRITTA, EDOKA . "Tandem Amidation Catalysis In The Synthesis Of Diazaphenoxazinecarboxamides Of Pharmaceutical Interest" Afribary (2021). Accessed May 01, 2024. https://afribary.com/works/tandem-amidation-catalysis-in-the-synthesis-of-diazaphenoxazinecarboxamides-of-pharmaceutical-interest