The Diagnostic Accuracy, Sensitivity And Specificity Of Fine Needle Aspiration Cytology In Evaluating Thyroid Masses At Moi Teaching And Referral Hospital

ABSTRACT

Thyroid masses are common surgical presentations with a worldwide prevalence of 4–7% in

the general adult population. Africa, specifically Kenya is not excluded from these surgical

conditions. The vast majority of adult thyroid nodules are benign neoplasm’s, however, less

than 10% are malignant, which makes it important to screen the nodules in order to offer

appropriate surgery and avoid unnecessary surgery for benign nodules. It is preferred to

operate only on those patients with suspicion of malignancy, while strict patient follow-up is

necessary in dealing with benign cases. Fine needle aspiration cytology (FNAC) is known to

play a pivotal role in the screening and management of thyroid swellings. FNAC is done in

an increasing number of patients presenting with thyroid masses at the Moi Teaching and

Referral Hospital, however its findings are yet to be incorporated into the management and

planning of these masses. The aim of this study was to assess the diagnostic accuracy of

FNAC in evaluating thyroid nodules at the Moi Teaching and Referral Hospital in order to

establish a basis of whether or not to incorporate its findings in the management of these

masses pre-operatively. This was a retrospective study where FNAC and corresponding

histological evaluation findings of 118 patients aged 17-88 years who had a pre-operative

FNAC and subsequently a thyroid resection for definitive histological diagnosis between

January 2007 and December 2014 were randomly sampled and accessed from the archives of

MTRH and compared for concordance and discordance. Of the 118 FNAC, 17 (14.40%)

were inadequate to make a diagnosis, 14(11.86%) were suspicious for malignancy, and 78

(66.1%) were benign while 9 (7.62%) were malignant. The benign cases consisted

predominantly of colloid goiter (54.54%) whereas the malignant ones consisted

predominantly of papillary carcinomas (5.08%). The concordance, false positive and false

negative rates were 90.80%, 3.44% and 5.74% respectively. The accuracy, sensitivity,

specificity, positive predictive value and negative predictive values of FNAC were 90.80%,

54.54%, 96.05%, 66.66% and 94.58% respectively. There was a significant agreement

between the two tests (p= 0.34). FNAC of thyroid is accurate and has a low rate of falsenegatives

and false-positives diagnoses hence can be adopted and relied upon in evaluating

thyroid nodules pre-operatively. Use of FNAC reduces the rate of unnecessary surgeries, the

cost of health care and the risks associated with surgeries, resulting in better outcome of

patients care.