Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines.
Nwuba, R , Sodeinde, O , Anumudu, C , Omosun, Y , Odaibo, A , Holder, A & Nwagwu, M (2021). The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies. Afribary. Retrieved from https://afribary.com/works/the-human-immune-response-to-plasmodium-falciparum-includes-both-antibodies-that-inhibit-merozoite-surface-protein-1-secondary-processing-and-blocking-antibodies
Nwuba, Roseangela et. al. "The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies" Afribary. Afribary, 11 Mar. 2021, https://afribary.com/works/the-human-immune-response-to-plasmodium-falciparum-includes-both-antibodies-that-inhibit-merozoite-surface-protein-1-secondary-processing-and-blocking-antibodies. Accessed 26 Dec. 2024.
Nwuba, Roseangela, Olugbemiro Sodeinde , Chiaka Anumudu , Yusuf Omosun , Alexander Odaibo , Anthony Holder and Mark Nwagwu . "The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies". Afribary, Afribary, 11 Mar. 2021. Web. 26 Dec. 2024. < https://afribary.com/works/the-human-immune-response-to-plasmodium-falciparum-includes-both-antibodies-that-inhibit-merozoite-surface-protein-1-secondary-processing-and-blocking-antibodies >.
Nwuba, Roseangela , Sodeinde, Olugbemiro , Anumudu, Chiaka , Omosun, Yusuf , Odaibo, Alexander , Holder, Anthony and Nwagwu, Mark . "The Human Immune Response to Plasmodium falciparum Includes Both Antibodies That Inhibit Merozoite Surface Protein 1 Secondary Processing and Blocking Antibodies" Afribary (2021). Accessed December 26, 2024. https://afribary.com/works/the-human-immune-response-to-plasmodium-falciparum-includes-both-antibodies-that-inhibit-merozoite-surface-protein-1-secondary-processing-and-blocking-antibodies