Abstract
Background: Some MSP-119 specific antibodies that inhibit merozoite invasion also inhibit the secondary processing of
MSP-1. However the binding of these inhibitory antibodies can be blocked by another group of antibodies, called blocking
antibodies, which recognize adjacent or overlapping epitopes, but themselves have no effect on either MSP-1 processing or
merozoite invasion. These antibodies have been reported to be present in individuals living in a malaria endemic area.
Methods: Blood samples were obtained from children shown to have processing inhibitory, blocking, and neutral antibodies
in a previous study. Enzyme linked immunosorbent assay (ELISA), was used to determine the total IgG, IgM and IgG
subtypes.
Results: There was a significant difference in anti-MSP-119 IgG, while there was no significant difference in the anti-MSP-119
IgM. Only anti MSP-119 IgG1, amongst the IgG subtypes was significantly different between the groups.
Conclusion: This study shows that antibodies against MSP-1 are different not only in specificity and function but also in
the amount of total IgG and IgG subtype produced.
Key Words: IgG subtypes; MSP-1; malaria
African Health Sciences 2010; 10(2): 106 - 110
YO¹, O , S¹§, A , CI2, A , A2, O , AA3, H & and, N (2021). Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodie. Afribary. Retrieved from https://afribary.com/works/total-immunoglobulin-g-and-igg1-subclass-levels-specific-for-the-msp-119-of-plasmodium-falciparum-are-different-in-individuals-with-either-processing-inhibitory-blocking-or-neutral-antibodies
YO¹, Omosun et. al. "Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodie" Afribary. Afribary, 20 Apr. 2021, https://afribary.com/works/total-immunoglobulin-g-and-igg1-subclass-levels-specific-for-the-msp-119-of-plasmodium-falciparum-are-different-in-individuals-with-either-processing-inhibitory-blocking-or-neutral-antibodies. Accessed 05 May. 2024.
YO¹, Omosun, Adoro S¹§ , Anumudu CI2 , Odaibo A2 , Holder AA3 and Nwagwu And . "Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodie". Afribary, Afribary, 20 Apr. 2021. Web. 05 May. 2024. < https://afribary.com/works/total-immunoglobulin-g-and-igg1-subclass-levels-specific-for-the-msp-119-of-plasmodium-falciparum-are-different-in-individuals-with-either-processing-inhibitory-blocking-or-neutral-antibodies >.
YO¹, Omosun , S¹§, Adoro , CI2, Anumudu , A2, Odaibo , AA3, Holder and And, Nwagwu . "Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodie" Afribary (2021). Accessed May 05, 2024. https://afribary.com/works/total-immunoglobulin-g-and-igg1-subclass-levels-specific-for-the-msp-119-of-plasmodium-falciparum-are-different-in-individuals-with-either-processing-inhibitory-blocking-or-neutral-antibodies