ADVERSE DRUG REACTION: A LOCAL AND GLOBAL PUBLIC HEALTH MENACE
Adverse drug reactions (ADR) occur frequently and globally, accounting for a significant number of fatalities each year.1, 2 Drugs remain the most common medical interventions used to relieve sufferings, but could also prove fatal. As the saying goes ‘‘Drugs are Double Edged Weapons’’ 1 and nearly all medicines are capable of causing injuries.
Systematic review and meta-analysis of the effectiveness of Rifapentine plus isoniazid compared with isoniazid monotherapy in preventing active tuberculosis in HIV positive adults
Background Tuberculosis is the highest cause of death in persons infected with HIV hence the need for prevention. The gold standard of self- administered isoniazid for 6 to 12 months is effective but adherence is poor and causes more adverse events. Rifapentine plus isoniazid for 3months administered under DOTS have limited treatment duration and may result in higher adherence and reduced adverse events. Objectives To determine the effectiveness of Rifapentine plus Isoniazid compared with i...