Assessment Of Lipase Enzyme, Cholesterol And Triglycerides Among Sudanese Post-Menopausal Women In Khartoum State

Abstract

Background: Menopause is a natural event in the ageing process and signifies the end of reproductive years with cessation of cyclic ovarian function as manifested by cyclic menstruation. Lipid profile is altered in menopause because of various reasons.

Objectives: The aim of this study to evaluate cholesterol, triglycerides and lipase enzyme among Sudanese normal premenopausal women and postmenopausal women.

Materials and methods: This is a case control study carried out in Saba’a center- Khartoum State during September 2019, to evaluate the level of cholesterol, triglycerides and lipase in postmenopausal women and normal premenopausal women. 50 postmenopausal women and 50 healthy premenopausal women were enrolled in this study after taking their verbal consent.

Result: The results showed that, 68% of post menopause women over 55 years old, while 32% less than 55 years old. The result showed that, there were significant increase in triglyceride and cholesterol levels and significant decrease in hepatic lipase enzyme among postmenopausal women when compare with control group, (183.8±37.49 versus 82.12±12.33, p-value =0.00) for triglyceride.( 238.9±30.08 versus 130.2±28.45 , p-value =0.00) for cholesterol. (89.70±28.38 versus 104.3±38.95, p-value =0.035) for lipase. There was significant positive correlation between lipase enzyme and age in post menopausal women (r=0.462, p- value=0.001) , There were no correlation between triglyceride , cholesterol and age (r=-0.201, p- value=0.162) (r=0.148,p- value= 0.306) respectively. Also there were no correlation between triglyceride, cholesterol and lipase (r=0.017, p- value=0.908) (r=0.141, p- value= 0.329) respectively.

Conclusion: The study was observed that postmenopausal women have a significant increase in triglyceride and cholesterol and significant decrease in lipase enzyme level. There was significant positive correlation between lipase enzyme and age in post menopausal women.