Research Papers/Topics in Medical Lab Science and Tech

Effects of Botanicals and Biocontrol Agents on Growth and Aflatoxin Production by Aspergillus Flavus Infecting Maize in Some Parts of Nigeria

ABSTRACT In a comprehensive study to assess the effects of botanicals and biocontrol agents on growth and aflatoxin (AF) production by Aspergillus flavus (A. flavus) infecting maize, a total of 1143 maize samples, collected in eighteen batches of five maize varieties (yellow, white, pop, variegated and mixed) from northern and southern parts of Nigeria were investigated between June 2011 to December 2013. Samples collected from field, 414 (36.2%) and stored batches, 729 (63.8%) were cultured...

The Effect of Ocimum Tenuiflorum (Nchuanwu) Leaf Extract on Hematolgical Parameters of Immumnosuppressed Albino Rats.

ABSTRACT The effect of Ocimum tenuiflorum on hematological parameters in immunosuppressed albino rats was investigated in this study. The aqueous (AE) and methanol extract (ME) of the leaf were obtained. Acute toxicity study was done to determine the LD50 of the leaf extract. Rats of mixed sexes, aged 2- 3months, weighing 150 to 240 grams were used. The rats were divided into 8 groups A-H of four rats each. Group A served as normal control. Immunesuppression was induced using 3mg/kg bodyweig...

Serum Levels of Proinflammatory Cytokines, Haptoglobin in Children of Various Abo Blood Group and Heamoglobin-Genotype with P. Falciparaum Malaria in Nnewi, Nigeria

ABSTRACT Malaria is characterized by marked changes in cytokine production from immune responses to infection (Jurgen, 2007). Genetics influences these variations in cytokine expression and ABO blood group and haemoglobin phenotype are genetic expressions (Deepa et al, 2011). Acute phase proteins may also be involved in cytokine induced replication of inflammatory processes (Warren (2010). This case controlled study involving children with plasmodium falciparum malaria (PFM) in Nnewi, Nigeri...

Assessment of Sensitivity and Specifity Immunochromatograophy Test And ELISA for detecting Human Immunodeficiency Virus Antibodies among Screening Patients in Khartoum State

Abstract  Human Immunodeficiency Virus ( HIV) is global and serious problem , with increase in mortality and morbidity worldwide. This was prospective , descriptive and cross sectional study aimed to assess the level of HIV Ab using the ICT and ELISA for detecting Ab and Ag (p24) .It was conducted among Screening patient in Khartoum state (National Public Health Laboratory) from 1 April to 30 June (2015) on a total of eighty nine (n=89)to compare the sensitivity and specificity of immunochro...

Measurement of Complete Blood Count (CBC) in alcohol consumer – Khartoum 2014

Abstract This is a prospective case control study to investigate the effect of alcohol consumption on complete blood count (CBC) of alcohol consumers in Khartoum State from April to July 2014.The participants were 80 apparently healthy adult males; 50 of them are alcohol consumers and 30 are non-alcoholic (control).Their age was (41 ±7.3years).A questionnaire was constructed to obtain information about the participants after an informed verbal consent from all the participants. Ethical appr...

Molecular Basis of Immunological Dysfunction in People Living with HIV and AIDS in Enugu, Nigeria

ABSTRACT Molecular basis of immunological dysfunction in people living with HIV and AIDS was studied among HIV-positive people attending clinics at the University of Nigeria Teaching Hospital Ituku-Ozalla, Annunciation Specialist Hospital Emene, Mother of Christ Specialist Hospital and Enugu State University Teaching Hospital, all in Enugu metropolis. A total of 90 subjects recruited for the study were divided into three groups: 30 diagnostically positive HIV subjects (A), 30 HIV-positive sub...

Analysis of Heavy Metals in Pleurotus Tuberregium Sclerotia,Toxicity in Blood, Bone Marrow and Some Selected Organs of Albino Rats

ABSTRACT Pleurotus tuberregium is a common mushroom which is used as food or medicine, more commonly as a vegetable soup thickener. This study investigated the presence of heavy metals in wild samples of pleurotus tuberregium sclerotia consumed within our localities, compared the degree of heavy metal contamination of the samples, investigated the presence of heavy metals in the serum of albino rats due to its consumption and the effects of its consumption on blood, bone marrow, liver and kid...

Potential for the Prediction of Prostate Cancer Risk Using Haplotypes in Exon 5 of Klk2 Gene

ABSTRACT BACKGROUND: Prostate cancer is the most common neoplasia of middle aged men .Early detection is problematic due to the lack of marker that has high sensitivity and specificity. Our aim was to genetically predict the possibility of developing prostate cancer using haplotypes in exon 5 of kLk2 gene. We evaluated polymorphisms in human glandular kallikreins 2 (KLK2) genes because a protein product of this gene is known to be increased in prostate cancer. SUBJECTS AND METHODS: Blood samp...

ABH Prevalence, Cd4 and Cd8 Levels in Secretors and Non-Secretors of ABH Antigens Among HIV Positive Individuals in Abakaliki Area of South-East Nigeria.

ABSTRACT Sixty(60)patients (31 males and 29 females) with Human immunodeficiency Virus (HIV) disease attending Ebonyi State University Teaching Hospital (EBSUTH) Abakaliki were used for the study. Sixty (60) age and sex matched apparently healthy individuals(34 males and 26 females) who were screened three months prior to study and then rescreened immediately the study started, served as the control group. Secretor status of the groups (test and control) were determined, using neutralization ...

Haemopoietic and Haematinic Property of the Leaf and Fruit Extract of Solanum Nigrum L (Spp Villosum) in Anaemic Albino Wistar Rats

ABSTRACT Anaemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as colonial and economic development. There is paucity of data on the use and type of medicinal plants that can be used to alleviate anaemia. Sequel to the fact that orthodox medicine can no longer give answers to our numerous different diseases in which anaemia is one of them. There is an increasing interest in the use of herbal products to sup...

Assessment of Biochemical Markers of Iron and Some Haematological Parameters on Blood Donors in Enugu State

ABSTRACT Iron deficiency is one of the most common of the nutritional deficiencies. The eventual consequence of iron deficiency is iron deficiency anemia; where the body stores of iron have been depleted and the body is unable to maintain level of hemoglobin in the blood. Blood donation leads to a substantial iron loss, as about 0.5mg iron is lost per each milliliter of blood donated. It is evident that haemoglobin level alone is inadequate for detecting blood donors with iron deficiency with...

Assessment of Tinea Infections Among Primary School Children in Aninri Local Government Area of Enugu State, Nigeria

Abstract Tinea infection is a common fungal infection that affects the superficial keratinized tissues of the body (skin, hair and nails). This study assessed tinea infections among primary school children in Aninri Local Government Area of Enugu State, Nigeria. Seven primary schools were selected for the study. Ethical approval was obtained from the Education and Health Departments of Aninri Local Government and informed consent also obtained from the parents of the pupils. A researcher-deve...

Immuno-Pathological Markers in Hiv/Aids Infection

ABSTRACT The AIDS pandemic and discovery of HIV, has produced a cohort of patients that thrust immunodeficiency and its associated infections into the lime light. Some opportunistic infections are indicators of HIV infection and are termed AIDS defining illnesses by the center for disease control and prevention. This study assesses the relationship between markers of HIV disease progression (AIDS defining illnesses) and CD4 lymphocyte count. Sputum samples of 234 HIV positive patients were an...

Hemostatic and Hematological Studies of Aqueous Extract of Bidens Pilosa in Wistar Rats

ABSTRACT Bidens pilosa L. (Asteraceae) also known as hairy beggar ticks, common names include; ‘Ogwunma’; 'Gyeya'(Igbo, Birom, Nigeria) and is one of the medicinal plant species worldwide. Among the Birom tribes in Plateau State, Nigeria Bidens pilosa is used as vegetable to prepare the local delicacy called ghote and also the sap from crushed leaves is used to speed up clotting of blood in fresh wounds. The aim of the study was to evaluate the effect of aqueous extract of Bidens pilosa l...


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