ABSTRACT
This study was done to evaluate the physicochemical properties, quality control parameters and
the dissolution profiles of circulating samples of artemether/lumefantrine sold at Pharmacies in
Kampala. The physicochemical parameters and assay of thirteen ( 13) brands of the products
were assessed through the evaluation of uniformity of tablet weight, friability test, disintegration
test and assay of active pharmaceutical ingredients according to established methods.
The dissolution rate was determined according to the USP SALMOUS Standard.
All brands complied with official requirements for uniformity of weight and friability.
The disintegration time had higher time in artificial gastric medium relative to distilled water.
Evaluation of content of active ingredients revealed that 38.5 percent of tested samples were
failing test for assay.
With the exception of three brands, all the brands complied with the requirements for dissolution
test.
Overall, 54 percent of the brands conformed to all the compendia specifications and 46 percent
were substandard.
Future studies should test for a greater number of samples per batch, aim at comparing
dissolution profile in various biological medium and investigate reasons for poor dissolution performance of some brands.
KIMONG, K (2021). Assessment Of The Quality And Dissolution Profiles Of Branded Fixed Dose Artemetherilumefantrine Tablets Sold At Pharmacies In Kampala- Uganda. Afribary. Retrieved from https://afribary.com/works/assessment-of-the-quality-and-dissolution-profiles-of-branded-fixed-dose-artemetherilumefantrine-tablets-sold-at-pharmacies-in-kampala-uganda
KIMONG, KIDEGA "Assessment Of The Quality And Dissolution Profiles Of Branded Fixed Dose Artemetherilumefantrine Tablets Sold At Pharmacies In Kampala- Uganda" Afribary. Afribary, 11 Jun. 2021, https://afribary.com/works/assessment-of-the-quality-and-dissolution-profiles-of-branded-fixed-dose-artemetherilumefantrine-tablets-sold-at-pharmacies-in-kampala-uganda. Accessed 19 Apr. 2024.
KIMONG, KIDEGA . "Assessment Of The Quality And Dissolution Profiles Of Branded Fixed Dose Artemetherilumefantrine Tablets Sold At Pharmacies In Kampala- Uganda". Afribary, Afribary, 11 Jun. 2021. Web. 19 Apr. 2024. < https://afribary.com/works/assessment-of-the-quality-and-dissolution-profiles-of-branded-fixed-dose-artemetherilumefantrine-tablets-sold-at-pharmacies-in-kampala-uganda >.
KIMONG, KIDEGA . "Assessment Of The Quality And Dissolution Profiles Of Branded Fixed Dose Artemetherilumefantrine Tablets Sold At Pharmacies In Kampala- Uganda" Afribary (2021). Accessed April 19, 2024. https://afribary.com/works/assessment-of-the-quality-and-dissolution-profiles-of-branded-fixed-dose-artemetherilumefantrine-tablets-sold-at-pharmacies-in-kampala-uganda