ABSTRACT
Background: Bacterial meningitis, is an inflammation of the meninges affecting the
pia, arachnoid, and subarachnoid space that happens in response to bacteria and
bacterial products invasion. The incidence of ABM has decreased significantly in
developed countries especially after the addition of the Hib and pneumococcal
conjugate vaccines to the routine childhood immunization schedule, but in most
developing countries little is known on how the introduction of these vaccines has
changed the incidence of ABM especially due to the existence of other comorbidities
such as HIV and malnutrition.
Objectives: Determination of prevalence, bacterial isolates and their antimicrobial
resistant pattern, and in hospital treatment outcome of acute bacterial meningitis
among children aged 2 months and 15 years who are suspected to have CNS
infection admitted at DRRH.
Methods: The study included a sample size of 101 patients aged 2 months to 15
years with features of CNS infection. The CSF obtained from these patients was
analyzed by using culture, gram stain and latex agglutination test for identifying the
etiological organism of ABM. MRDT, BS and CRAG to all HIV patients to rule out
other causes of CNS infection.
Results: The prevalence of ABM was found to be 4 %( 4/101). 1 species of E. coli
and 3 species of S. pneumoniae were the main organism isolated. Severe acute
malnutrution was found to be one of the major risk factors with a (OR5.3,
95%CI[2.005-5.924] p -value 0.04) while being immunized at least once against the
common causative organisms was found to be protective against ABM with a p value
vi
of 0.04 ( OR0.04,95CI[ 0.02-0.9] p value 0.04). This disease was among the risks
factors for requirement of physiotherapy at the time of discharge with (OR2.36 95CI
[1.18- 19.7] p value 0.047)
Conclusion: Despite wide spread of vaccination coverage, ABM is still prevalent
with a local prevalence at Dodoma RRH of 4%. Children with Severe acute
malnutrition were found to be at high risk for this ABM. Streptococcus pneumoniae
which were the main isolates, had a resistance of about 50% to the first line
antibiotics used for ABM. At discharge, children confirmed to have ABM were
more likely to have neurological deficits requiring physiotherapy.
Hence more efforts should be placed on diagnosis and identification of etiological
organisms by using high sensitive techniques so as to improve treatment and
outcome among patients with ABM
Frontiers, E. & KIPIKI, N (2021). Common Bacterial Isolates And In Hospital Treatment Outcome Of Acute Bacterial Meningitis Among Children Suspected With Central Nervous System Infections Admitted At Dodoma Regional Referral . Afribary. Retrieved from https://afribary.com/works/common-bacterial-isolates-and-in-hospital-treatment-outcome-of-acute-bacterial-meningitis-among-children-suspected-with-central-nervous-system-infections-admitted-at-dodoma-regional-referral-
Frontiers, Edu, and NEEMA KIPIKI "Common Bacterial Isolates And In Hospital Treatment Outcome Of Acute Bacterial Meningitis Among Children Suspected With Central Nervous System Infections Admitted At Dodoma Regional Referral " Afribary. Afribary, 22 May. 2021, https://afribary.com/works/common-bacterial-isolates-and-in-hospital-treatment-outcome-of-acute-bacterial-meningitis-among-children-suspected-with-central-nervous-system-infections-admitted-at-dodoma-regional-referral-. Accessed 30 Jun. 2022.
Frontiers, Edu, and NEEMA KIPIKI . "Common Bacterial Isolates And In Hospital Treatment Outcome Of Acute Bacterial Meningitis Among Children Suspected With Central Nervous System Infections Admitted At Dodoma Regional Referral ". Afribary, Afribary, 22 May. 2021. Web. 30 Jun. 2022. < https://afribary.com/works/common-bacterial-isolates-and-in-hospital-treatment-outcome-of-acute-bacterial-meningitis-among-children-suspected-with-central-nervous-system-infections-admitted-at-dodoma-regional-referral- >.
Frontiers, Edu and KIPIKI, NEEMA . "Common Bacterial Isolates And In Hospital Treatment Outcome Of Acute Bacterial Meningitis Among Children Suspected With Central Nervous System Infections Admitted At Dodoma Regional Referral " Afribary (2021). Accessed June 30, 2022. https://afribary.com/works/common-bacterial-isolates-and-in-hospital-treatment-outcome-of-acute-bacterial-meningitis-among-children-suspected-with-central-nervous-system-infections-admitted-at-dodoma-regional-referral-