Background: Lidocaine, is an important anesthetic and anti-arrhythmic drug, widely used in medicine,
at the same time a danger. The impurity 2, 6-xylidine is the starting material for its manufacture,
degradation product of lidocaine on storage and metabolite when administered. This study seeks to
identify 3 brands of lidocaine in Uganda Pharmacies, assess level of impurity and drug content by a
comparative pharmacopoeial chemical analysis.
Aim: To do a comparative pharmacopoeial analysis of the selected brands of Lidocaine 2% injection in
the volumes of 20ml that are within the shelf life of the drug and must be on the NDA approved list of
Drugs in Uganda.
Methods: Sample of each brand of Lidocaine was reacted and with 2ml of 10% cobalt II Chloride to
form a greenish blue precipitate. Secondly, the melting point of a salt formed with picric acid was
determine by capillary method. The colour intensity produced when samples reacted with 1% Pdimethyl
amino benzaldehyde was compared with the standard 400pp 2, 6-DMA solution in 10 mi. A
non-aqueous titration was performed with 5ml extract of each sample using crystal violet as indicator
and 0.02M perchloric acid as titrant. Each ml of0.02M HCL04 = 5.776mg of Lidocaine (BP, 2009).
Results: All brands were identified to be lidocaine, with levels of2, 6-Dimethyl aniline less than 400ppm
and drug concentration within the range 95 to 105% (BP, 2009). Conclusion: All brands of lidocaine complied with the pharmacopoeial standards.
SSA, R (2021). Comparative Pharmacopoeial Analysis Of Three Brands Of Lidocaine 2°/O Injection Available In Uganda Pharmacies. Afribary.com: Retrieved June 23, 2021, from https://afribary.com/works/comparative-pharmacopoeial-analysis-of-three-brands-of-lidocaine-20-o-injection-available-in-uganda-pharmacies
Research, SSA. "Comparative Pharmacopoeial Analysis Of Three Brands Of Lidocaine 2°/O Injection Available In Uganda Pharmacies" Afribary.com. Afribary.com, 11 Jun. 2021, https://afribary.com/works/comparative-pharmacopoeial-analysis-of-three-brands-of-lidocaine-20-o-injection-available-in-uganda-pharmacies . Accessed 23 Jun. 2021.
Research, SSA. "Comparative Pharmacopoeial Analysis Of Three Brands Of Lidocaine 2°/O Injection Available In Uganda Pharmacies". Afribary.com, Afribary.com, 11 Jun. 2021. Web. 23 Jun. 2021. < https://afribary.com/works/comparative-pharmacopoeial-analysis-of-three-brands-of-lidocaine-20-o-injection-available-in-uganda-pharmacies >.
Research, SSA. "Comparative Pharmacopoeial Analysis Of Three Brands Of Lidocaine 2°/O Injection Available In Uganda Pharmacies" Afribary.com (2021). Accessed June 23, 2021. https://afribary.com/works/comparative-pharmacopoeial-analysis-of-three-brands-of-lidocaine-20-o-injection-available-in-uganda-pharmacies