Abstract
Background: The ability of the host immune system to efficiently clear Plasmodium falciparum parasites during a malaria infection
depends on the type of immune response mounted by the host.
Study design: In a cross-sectional study, we investigated the cellular-and antibody responses in individuals with P. falciparum
infection, in an attempt to identify immunological signs indicative of the development of natural immunity against malaria in Ibadan,
Nigeria. Levels of IL-10, IL-12(p70), IFN-γ, and IgM, IgG and IgG1-4 subclasses in the serum of 36 symptomatic children with
microscopically confirmed malaria parasitaemia and 54 asymptomatic controls were analysed by ELISA.
Results: IFN-γ and IL-10 were significantly higher in the symptomatic children (p=0.009, p=0.025 respectively) than in the
asymptomatic controls but no differences were seen for IL-12(p70). Estimated higher ratios of IFN-γ/IL-10 and IFN-γ/IL-12 were
also observed in the symptomatic children while the asymptomatic controls had higher IL-12/IL-10 ratio. The mean concentration
levels of anti-P. falciparum IgG1, IgG2, IgG3 antibodies were statistically significantly higher in the individuals >5 years of age than
Iriemenam, N (2021). Cytokine profiles and antibody responses to Plasmodium falciparum malaria infection in individuals living in Ibadan, southwest Nigeria. Afribary. Retrieved from https://afribary.com/works/cytokine-profiles-and-antibody-responses-to-plasmodium-falciparum-malaria-infection-in-individuals-living-in-ibadan-southwest-nigeria
Iriemenam, Nnaemeka "Cytokine profiles and antibody responses to Plasmodium falciparum malaria infection in individuals living in Ibadan, southwest Nigeria" Afribary. Afribary, 20 Apr. 2021, https://afribary.com/works/cytokine-profiles-and-antibody-responses-to-plasmodium-falciparum-malaria-infection-in-individuals-living-in-ibadan-southwest-nigeria. Accessed 28 Apr. 2024.
Iriemenam, Nnaemeka . "Cytokine profiles and antibody responses to Plasmodium falciparum malaria infection in individuals living in Ibadan, southwest Nigeria". Afribary, Afribary, 20 Apr. 2021. Web. 28 Apr. 2024. < https://afribary.com/works/cytokine-profiles-and-antibody-responses-to-plasmodium-falciparum-malaria-infection-in-individuals-living-in-ibadan-southwest-nigeria >.
Iriemenam, Nnaemeka . "Cytokine profiles and antibody responses to Plasmodium falciparum malaria infection in individuals living in Ibadan, southwest Nigeria" Afribary (2021). Accessed April 28, 2024. https://afribary.com/works/cytokine-profiles-and-antibody-responses-to-plasmodium-falciparum-malaria-infection-in-individuals-living-in-ibadan-southwest-nigeria