Detection And Management Of Adverse Drug Reactions Related To Antiretrovirals Among Hiv/Aids Patients In Kiambu District, Kenya

ABSTRACT

Acquired Immune Deficiency Syndrome (AIDS) is one of the most significant infections to appear in the recent times. Worldwide it is estimated that 33.4 million people are living with the syndrome 68% of whom are in Sub-Saharan Africa. There are 4 million people worldwide on treatment although another 5 million eligible for treatment do not have access to life prolonging treatment and care. Antiretroviral drugs are used to prolong and improve the quality of life for those infected. This therapy is associated with side effects and adverse drug reactions (ADRs) of varying degrees in frequency and severity. A better understanding of adverse effects is of interest not only to the HIV specialists as they try to optimize on therapy but also to the patient who may not be aware of these adverse reactions due to the multiple symptoms associated with the AIDS syndrome. Not much is known about ADRs in Kenya because most knowledge is from the West where research and capacity to react comprehensively to research in clinical challenges posed by the syndrome is sufficient. The objective of this study was to establish the prevalence, detection and management of various ADRs occurring in patients attending Comprehensive Care Centre of Kiambu District Hospital. The study was a cross sectional survey where patients included were those attending the Comprehensive Care Centre on a monthly basis. The patients were selected by convenience sampling depending on their ability and willingness to participate in the study. Data was collected from 354 respondents using an investigator- administered questionnaire. Analysis was done using SPSS version 11.50 software. Chi-square test was used to test significance and logistic regression carried out to determine the independent effect of selected variables on occurrence of ADRs. Statistical tests were performed at 5% (P=0.05) level of significance. The results revealed that 65.2% of the patients had experienced symptoms suggestive of ADRs. Of these, 67.2% did not associate the symptoms to the medicines they were taking but rather to the disease. The most prominent ADR was peripheral neuropathy at 0.395 (95% CI 0.344, 0.447) while the least common was hepatotoxicity. Whereas 71.5% could tell the frequency of the daily dosage, 92.1% did not know the names of the medicines they were taking but could describe them by shape and colour. There was a significant association between occurrence and reporting of ADRs and age (P

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APA

NDERITU, F (2021). Detection And Management Of Adverse Drug Reactions Related To Antiretrovirals Among Hiv/Aids Patients In Kiambu District, Kenya. Afribary. Retrieved from https://afribary.com/works/detection-and-management-of-adverse-drug-reactions-related-to-antiretrovirals-among-hiv-aids-patients-in-kiambu-district-kenya

MLA 8th

NDERITU, FLORENCE "Detection And Management Of Adverse Drug Reactions Related To Antiretrovirals Among Hiv/Aids Patients In Kiambu District, Kenya" Afribary. Afribary, 31 May. 2021, https://afribary.com/works/detection-and-management-of-adverse-drug-reactions-related-to-antiretrovirals-among-hiv-aids-patients-in-kiambu-district-kenya. Accessed 26 May. 2024.

MLA7

NDERITU, FLORENCE . "Detection And Management Of Adverse Drug Reactions Related To Antiretrovirals Among Hiv/Aids Patients In Kiambu District, Kenya". Afribary, Afribary, 31 May. 2021. Web. 26 May. 2024. < https://afribary.com/works/detection-and-management-of-adverse-drug-reactions-related-to-antiretrovirals-among-hiv-aids-patients-in-kiambu-district-kenya >.

Chicago

NDERITU, FLORENCE . "Detection And Management Of Adverse Drug Reactions Related To Antiretrovirals Among Hiv/Aids Patients In Kiambu District, Kenya" Afribary (2021). Accessed May 26, 2024. https://afribary.com/works/detection-and-management-of-adverse-drug-reactions-related-to-antiretrovirals-among-hiv-aids-patients-in-kiambu-district-kenya