Background: Tuberculosis (TB) is a global public health menace especially in developing
countries where it contributes significantly to the top ten causes of mortality. In Eastern
region, the TB burden remains high and priority. The increasing trend of anti-TB drug
resistance is a great challenge. This study assessed the resistance pattern and factors
associated with MDR-TB cases among suspected MDR-TB cases in Eastern region, from
2014 to 2018.
Methods: This study was conducted in the Eastern region of Ghana using medical records
from 1st January 2014 to 31st December 2018. Variables studied were socio-demographic
factors, clinical, anthropometric and laboratory characteristics. Medical records were
entered into excel and imported into STATA version 15. Data were cleaned and analyzed
using STATA statistical analysis. Frequencies, proportions and tables were generated.
Pearson’s Chi-square test was used to determine factors associated with MDR-TB cases
and multiple logistic regression was used to determine the magnitude of association. A test
of significance was set at 0.05.
Results: All forms of MDR-TB accounted for 9.3% (47/503, 95% CI: 6.9-12.2) of cases
with 39.5% among new cases and 6.9% among previously treated cases. The overall
resistance to at least any of the first line anti-TB drugs was 39% (196/503) with Rifampicin
been the most resistant. HIV positive test results (aOR=3.80, 95% CI: 1.09-13.26), type of
case (aOR=0.07, 95% CI: 0.05-0.24) and sputum smear positive results (aOR=12.88, 95%
CI: 5.47-30.34) were significantly associated with MDR-TB.
Conclusion: One in every ten suspected MDR-TB case was confirmed MDR-TB. Burden
of MDR-TB was high in newly infected cases. Factors associated with MDR-TB were HIV
positive results, sputum smear positive results and type of case. Therefore, improving early
case detection and treatment, building capacity of laboratory for Drug Susceptibility
Testing (DST), strengthening TB infection control and prevention activities and complying
to DOTS strategy are recommended to minimize the menace of MDR-TB.
Edu, F (2021). Factors Associated With Multi-Drug Resistant (Mdr) Tuberculosis Among Suspected Mdr-Tb Cases In Eastern Region, 2014 – 2018. Afribary.com: Retrieved May 10, 2021, from https://afribary.com/works/factors-associated-with-multi-drug-resistant-mdr-tuberculosis-among-suspected-mdr-tb-cases-in-eastern-region-2014-2018
Frontiers, Edu. "Factors Associated With Multi-Drug Resistant (Mdr) Tuberculosis Among Suspected Mdr-Tb Cases In Eastern Region, 2014 – 2018" Afribary.com. Afribary.com, 27 Apr. 2021, https://afribary.com/works/factors-associated-with-multi-drug-resistant-mdr-tuberculosis-among-suspected-mdr-tb-cases-in-eastern-region-2014-2018 . Accessed 10 May. 2021.
Frontiers, Edu. "Factors Associated With Multi-Drug Resistant (Mdr) Tuberculosis Among Suspected Mdr-Tb Cases In Eastern Region, 2014 – 2018". Afribary.com, Afribary.com, 27 Apr. 2021. Web. 10 May. 2021. < https://afribary.com/works/factors-associated-with-multi-drug-resistant-mdr-tuberculosis-among-suspected-mdr-tb-cases-in-eastern-region-2014-2018 >.
Frontiers, Edu. "Factors Associated With Multi-Drug Resistant (Mdr) Tuberculosis Among Suspected Mdr-Tb Cases In Eastern Region, 2014 – 2018" Afribary.com (2021). Accessed May 10, 2021. https://afribary.com/works/factors-associated-with-multi-drug-resistant-mdr-tuberculosis-among-suspected-mdr-tb-cases-in-eastern-region-2014-2018