Research Papers/Topics in Biomedical Science

Computational Study of Dual Sensor Design For Noninvasive Diabetics Detection Device Based on Infrared And Ultrasound PIEZOELECTRIC MEMS Technologies

ABSTRACT Continuous and noninvasive method of monitoring and regulating the blood glucose level in diabetic patients is essential to avoid complications that may result from the condition. Over the last few years, efforts have been made to replace the existing invasive method of glycemic monitoring with the novel noninvasive approach by taking advantage of recent developments in biosensors and enhanced computing power of microprocessors. This work sought to explore the combined technolo...

Fabrication of a post-Operative Prosthesis- Quality of Life Among Lower Limb Prosthesis Users in Southern-Eastern Nigeria

ABSTRACT A major rehabilitation goal in the care of limb amputees is to minimize the negative effects of this type of disability by using prosthesis, thereby improving the quality of life (QoL). Studies on QoL of amputees are sparse in Nigeria. Studies on the adoption and use of Post Operative Prosthesis are inexistent. The present study designed and fabricated a post-operative prosthesis and as well researched on the QoL of prosthesis-using-amputees using the Trinity Amputation Prosthe...

Adenosine Deaminase Activity In The Diagnosis Of Tuberculous Meningitis And Its Levels In Other Diseases

ABSTRACT The diagnostic value of Adenosine Deaminase was studied to evaluate and establish a cut-off point for the diagnosis of tuberculous meningitis and also to establish its levels in other diseases in the local setting. There were 358 subjects in the study. The mean age of the adults was 29 ± 2; with a range of 13-74 years, while the age of the infants ranged from one day to 13 years. These were made up as follows: ‘Apparently healthy donors’ (30); tuberculous meningitis (...

Bcr-Abl1 Positive Acute Lymphoblastic Leukaemia In Ghanaian Patients

ABSTRACT Background: Acute lymphoblastic leukaemia (ALL) is the accumulation of lymphoblasts in the bone marrow as a result of malignant transformation resulting in proliferation of immature lymphoid progenitors or lymphoblasts. It results from perturbation of several genetic loci. The chimeric BCR-ABL1 gene fusion is one of such genetic alterations. Even though the presence of BCR-ABL1 has been associated with poor prognosis, the incorporation of tyrosine kinase inhibitors in treatment...

Antiplasmodial Activity And Cytochrome P450 Mediated Pharmacokinetic Drug Interactions Of Xylopic Acid

ABSTRACTXylopic acid (XA), the major constituent of the fruit of Xylopia aethiopica hasshown several pharmacological properties. Consequently, the fruit is being usedin the preparation of food. Traditionally, the plant is used to treat severaldiseases and it has been formulated into a nasal drop despite the lack ofinformation about its safety, food-drug interaction, and other pharmacokineticproperties. Therefore, this study investigated the antiplasmodial effect of XA onP. falciparum, and its...

COMPUTER–AIDED APPROACHES TO DISCOVERY OF NOVEL DRUGS AGAINST THE HUMAN HOOKWORM NECATOR AMERICANUS (NEMATODA: ANCYLOSTOMATIDAE)

ABSTRACT There is a crucial need to develop novel anthelminthic drugs due to the mounting disease burden and increasing evidence of hookworm resistance to drugs such as albendazole and mebendazole, which for decades have been used to treat the infection. Consequently, it is exigent to develop alternative drugs with improved therapeutic efficacy. Natural products due to their unique active ingredients have been shown to possess exceptional structures with chemical diversity that is unmat...

THE PREVALENCE OF HEPATITIS B AND C VIRUS INFECTIONS AMONG LIVER CIRRHOSIS PATIENTS AT THE KORLE-BU TEACHING HOSPITAL, ACCRA-GHANA

ABSTRACTCirrhosis of the liver is an endstage chronic liver disease which is generally irreversible. About 75% of patients with posthepatitic cirrhosis have progressive disease despite supportive therapy and die within one to five years from serious complications such as variceal haemorrhage, hepatic encephalopathy or superimposed hepatocellular carcinoma. Records from the Pathology Department of the Korle-Bu Teaching Hospital, Accra-Ghana indicates that cirrhosis is ...

ANTI-HEPATOCELLULAR CARCINOMA EFFECT OF AN ALKALOIDAL EXTRACT DERIVED FROM ZANTHOXYLUM ZANTHOXYLOIDES

ABSTRACT Background: The global burden of Hepatocellular Carcinoma (HCC) has increased. Consequently, exploring newer treatment modalities for HCC such as herbal medicines has become a necessary. Objective: The study investigated antiHCC effects of an alkaloidal extract derived from leaves of Zanthoxylum zanthoxyloides. Materials and methods: Alkaloidal extract (ZZAE) from cleaned dried leaves of Zanthoxylum zanthoxyloides was prepared using Soxhlet extraction and liquid-liquid e...