Abstract
This is analytical retrospective case control study conducted at Ibn Seina Hospital and
Sudan University of Science and Technology-College of Medical Laboratory science
during the period from January to May 2016. The study aimed to detect E cadherin in
renal tumors among Sudanese patients using immunohistochemical method. 72
paraffin blocks samples were collected from patients previously diagnosed as renal
tumors (54 diagnosed as malignant renal tumors, 18 as benign renal tumors). Of whom
30 (41.6%) were male and 42 (58.4%) were female. Their ages ranged between 21 to
85 years with mean age 55 year. From each block one section was cut (3μm) by using
rotary microtome to detect E cadherin in renal tumors.
Data was analyzed using SPSS version 20 computer programs; mean, frequency and
chi square were calculated
E cadherin was positive in 43 (59.7%) samples, while 29 (40.3%) samples were
negative. From positive results, 17 (23.6%) in benign renal tumors, while 26 (36.1%)
in malignant renal tumors with significant differences between E cadherin expression
and renal tumors (P = 0.001). Positive result in malignant renal tumors distributed as
follow, 11 (20.4%) in papillary RCC, 7 (13%) in non classified tumors, 6 (11.1%) in
chromophobe RCC, and 2 (3.7%) in clear cell RCC with significant differences
between E cadherin expression and subtypes of malignant renal tumors (P = 0.000).
On the basis of these results the study concluded that, there is a relation between E
cadherin expression and benign renal tumors. There is a relation between E cadherin
expression and subtypes of malignant renal tumors, strongly expressed in chromophobe RCC and papillary RCC.
Dawood, A (2021). Immunohistochemical Expression of E cadherin in Renal Tumors. Afribary. Retrieved from https://afribary.com/works/immunohistochemical-expression-of-e-cadherin-in-renal-tumors
Dawood, Abubakr "Immunohistochemical Expression of E cadherin in Renal Tumors" Afribary. Afribary, 20 May. 2021, https://afribary.com/works/immunohistochemical-expression-of-e-cadherin-in-renal-tumors. Accessed 21 Nov. 2024.
Dawood, Abubakr . "Immunohistochemical Expression of E cadherin in Renal Tumors". Afribary, Afribary, 20 May. 2021. Web. 21 Nov. 2024. < https://afribary.com/works/immunohistochemical-expression-of-e-cadherin-in-renal-tumors >.
Dawood, Abubakr . "Immunohistochemical Expression of E cadherin in Renal Tumors" Afribary (2021). Accessed November 21, 2024. https://afribary.com/works/immunohistochemical-expression-of-e-cadherin-in-renal-tumors