ABSTRACT
Background: Childhood tuberculosis (TB) remains a major public health problem worldwide, especially in developing countries. Despite clear evidence that isoniazid preventive therapy (IPT) can reduce the risk of progression from TB infection to disease in TB contacts, uptake of IPT in children is low and IPT delivery is a challenge in many resource-limited settings with high TB-burden. Furthermore, the IPT initiation rates amongst child TB program implementation settings in Cameroon has not been reported and may be sub-optimal. Therefore, this study was carried out to determine the level of IPT uptake and its associated factors amongst child contacts of adults diagnosed with smear-positive pulmonary tuberculosis (SPPTB).
Methods: This was a mixed-method study involving quantitative and qualitative components. The quantitative component was conducted among child contacts of adult patients diagnosed with SPPTB (index case). Background, clinical, health facility, community and IPT related data were collected from 9 selected health facilities using interviewer administered questionnaires. Descriptive statistics was used to generate frequency tables and figures. Logistic regression analysis was performed to determine factors independently associated with IPT uptake. This was followed by qualitative phase which employed in-depth interviews (IDIs) with healthcare workers. The IDI sessions was taped, transcribed verbatim and analysed using a thematic approach.
Results: A total of 513 child contacts were included amongst which 118 (23.0%; 95% CI: 19.6-26.9) had received IPT. Index cases aged 21-30 years [OR=34.712; (95% CI: 4.801-250.998); p
CHIA, A (2021). ISONIAZIDE PREVENTIVE THERAPY UPTAKE AMONGST CHILD CONTACTS OF ADULTS DIAGNOSED WITH SMEAR POSITIVE PULMONARY TUBERCULOSIS IN SELECTED HEALTH FACILITIES IN DOUALA, CAMEROON. Afribary. Retrieved from https://afribary.com/works/isoniazide-preventive-therapy-uptake-amongst-child-contacts-of-adults-diagnosed-with-smear-positive-pulmonary-tuberculosis-in-selected-health-facilities-in-douala-cameroon
CHIA, AYEAH "ISONIAZIDE PREVENTIVE THERAPY UPTAKE AMONGST CHILD CONTACTS OF ADULTS DIAGNOSED WITH SMEAR POSITIVE PULMONARY TUBERCULOSIS IN SELECTED HEALTH FACILITIES IN DOUALA, CAMEROON" Afribary. Afribary, 16 Mar. 2021, https://afribary.com/works/isoniazide-preventive-therapy-uptake-amongst-child-contacts-of-adults-diagnosed-with-smear-positive-pulmonary-tuberculosis-in-selected-health-facilities-in-douala-cameroon. Accessed 18 May. 2024.
CHIA, AYEAH . "ISONIAZIDE PREVENTIVE THERAPY UPTAKE AMONGST CHILD CONTACTS OF ADULTS DIAGNOSED WITH SMEAR POSITIVE PULMONARY TUBERCULOSIS IN SELECTED HEALTH FACILITIES IN DOUALA, CAMEROON". Afribary, Afribary, 16 Mar. 2021. Web. 18 May. 2024. < https://afribary.com/works/isoniazide-preventive-therapy-uptake-amongst-child-contacts-of-adults-diagnosed-with-smear-positive-pulmonary-tuberculosis-in-selected-health-facilities-in-douala-cameroon >.
CHIA, AYEAH . "ISONIAZIDE PREVENTIVE THERAPY UPTAKE AMONGST CHILD CONTACTS OF ADULTS DIAGNOSED WITH SMEAR POSITIVE PULMONARY TUBERCULOSIS IN SELECTED HEALTH FACILITIES IN DOUALA, CAMEROON" Afribary (2021). Accessed May 18, 2024. https://afribary.com/works/isoniazide-preventive-therapy-uptake-amongst-child-contacts-of-adults-diagnosed-with-smear-positive-pulmonary-tuberculosis-in-selected-health-facilities-in-douala-cameroon