Q Fever Infection In Patients With Febrile Illness At Selected Healthcare Facilities In Ghana.

ABSTRACT BACKGROUND Q fever is a zoonotic infection transmitted by an intracellular bacterium Coxiella burnetii. The most frequently observed clinical feature of Q fever is acute febrile illness, or in rare cases, chronic illnesses. This disease is under-diagnosed and under-reported because the symptoms are nonspecific, resembling other febrile illnesses such as malaria. Due to similarity of Q fever clinical symptoms to malaria and other febrile illness aetiologies, misdiagnosis could lead to clinical complications. In Ghana little is known about Q fever, hence the need for the study. AIM The aim of this study was to investigate Q fever infection in patients reporting with febrile illness at selected healthcare facilities in Ghana. METHOD This was a cross-sectional study conducted at 37 Military hospital, Accra, and three military healthcare facilities in Sekondi-Takoradi. Participants‘ which included military personnel and civilians, demographic data, clinical features and exposure data were obtained using a questionnaire. Depending on age, between 2 and 10 ml of venous blood was collected from consenting febrile patients at the selected healthcare facilities. Serum was collected and screened for phase II immunoglobulins M and G by Enzyme Linked Immunosorbent Assay (ELISA). Part of the serum was extracted and used for real-time Polymerase Chain Reaction (rt-PCR) and Loop Mediated Isothermal (LAMP) assays. xi RESULTS A total of 117 febrile patients were recruited into the study comprising 64 (54.70%) males and 53 (45.30%) females. An overall seroprevalence of 16.24% was recorded, comprising of 6.83% for IgM (indicating current or acute infection) and 11.11% for IgG (indicating recent or past infection). Clinical manifestation in study participants showed no significant association with the infection. The occupation of the participant was a statistically significant risk factor, with the unemployed having a greater likelihood of acquiring the infection. C. burnetii could not be detected by both rt-PCR and LAMP assays, this may have been due to late sample collection after the onset of symptoms. CONCLUSION The study clearly suggests the presence of Q fever among febrile patients in Ghana and occupation was a significant risk factor to Q fever exposure. Active surveillance is recommended to properly identify the source of transmission of C. burnetii.

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APA

YEBOAH, C (2021). Q Fever Infection In Patients With Febrile Illness At Selected Healthcare Facilities In Ghana.. Afribary. Retrieved from https://afribary.com/works/q-fever-infection-in-patients-with-febrile-illness-at-selected-healthcare-facilities-in-ghana

MLA 8th

YEBOAH, CLARA "Q Fever Infection In Patients With Febrile Illness At Selected Healthcare Facilities In Ghana." Afribary. Afribary, 09 Apr. 2021, https://afribary.com/works/q-fever-infection-in-patients-with-febrile-illness-at-selected-healthcare-facilities-in-ghana. Accessed 12 Jul. 2024.

MLA7

YEBOAH, CLARA . "Q Fever Infection In Patients With Febrile Illness At Selected Healthcare Facilities In Ghana.". Afribary, Afribary, 09 Apr. 2021. Web. 12 Jul. 2024. < https://afribary.com/works/q-fever-infection-in-patients-with-febrile-illness-at-selected-healthcare-facilities-in-ghana >.

Chicago

YEBOAH, CLARA . "Q Fever Infection In Patients With Febrile Illness At Selected Healthcare Facilities In Ghana." Afribary (2021). Accessed July 12, 2024. https://afribary.com/works/q-fever-infection-in-patients-with-febrile-illness-at-selected-healthcare-facilities-in-ghana